Deconstructing stemness
Deconstructing stemness
复制标题
DOI：
10.1038/sj.emboj.7600749
复制
发表时间：
2005-08-03
期刊：
影响因子：
11.4
通讯作者：
Frisén, J
中科院分区：
文献类型：
--
作者：
Mikkers, H;Frisén, J
干细胞具有独特的自我更新和产生分化后代的能力，以维持整个生命的组织。一个共同的干细胞分子程序仍然难以捉摸。我们讨论什么是词干的分子逻辑。我们认为，它可能不耦合到不同的细胞特性，如自我更新或多能性，而是在特定的发展阶段的稳定悬浮液。从这个角度来看，干细胞小生境允许细胞保持转录可及性，从而能够产生特异性分化的后代。
Stem cells are unique in their capacity to self-renew and generate differentiated progeny to maintain tissues throughout life. A common molecular program for stem cells has remained elusive. We discuss what the molecular logic of stemness may be. We suggest that it may not be coupled to distinct cellular properties such as self-renewal or multipotency, but rather to the stable suspension at a specific developmental stage. In this view, the stem cell niche allows a cell to maintain a transcriptional accessibility enabling the generation of specific differentiated progeny.