Increased incidence of symptomatic peripheral neuropathy among adults receiving stavudine- versus zidovudine-based antiretroviral regimens in Kenya.
Increased incidence of symptomatic peripheral neuropathy among adults receiving stavudine- versus zidovudine-based antiretroviral regimens in Kenya.
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在肯尼亚，接受司他夫定与齐多夫定为基础的抗逆转录病毒治疗方案的成年人中，症状性周围神经病变的发生率增加。
DOI：
10.1007/s13365-012-0098-x
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发表时间：
2012
影响因子：
3.2
通讯作者：
Chung,MichaelH
中科院分区：
文献类型：
--
作者：
McGrath,ChristineJ;Njoroge,Julia;John-Stewart,GraceC;Kohler,PamelaK;Benki-Nugent,SarahF;Thiga,JoanW;Etyang,Anthony;Chung,MichaelH
The incidence of peripheral neuropathy (PN) among adults initiating antiretroviral therapy (ART) containing stavudine (d4T) versus zidovudine (ZDV) is not well described. We compared 1-year incidence between d4T- and ZDV-based regimens in adults initiating ART in a programmatic setting in Kenya. Of 1,848 adults on ART, 1,579 (85 %) initiated d4T-based and 269 (15 %) initiated ZDV-based regimens. One-year incidence of symptomatic PN per 100 person-years was 21.9 (n= 236) among d4T users and 6.9 (n= 7) among ZDV users (P= 0.0002). D4T was associated with 2.7 greater risk of PN than ZDV (adjusted hazard ratio, 2.7,P= 0.009). In settings with continued d4T use, such as Africa, the effects of d4T on PN compared to ZDV should be considered when choosing ART regimens.
