The Therapeutic Use of Antioxidants for Melasma
The Therapeutic Use of Antioxidants for Melasma
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DOI：
10.36849/jdd.2020.5079
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发表时间：
2020-08-01
影响因子：
1.5
通讯作者：
Khachemoune, Amor
中科院分区：
文献类型：
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作者：
Babbush, Kayla M.;Babbush, Remy A.;Khachemoune, Amor
黄褐斑是一种慢性皮肤病，其发病机制尚不完全清楚，对患者生活质量的影响已得到充分证实。黄褐斑是寻求皮肤科护理的常见原因，并且没有普遍有效的治疗或治愈，联合治疗是许多情况下的最佳方法。许多研究已经证明了氧化应激在黄褐斑患者中的作用，促使人们研究几种抗氧化剂用于黄褐斑治疗。在这篇综述中，我们讨论了氧化应激在黄褐斑中的作用，以及各种抗氧化剂对黄褐斑患者的治疗效果。我们的讨论集中在研究维生素C，壬二酸，半胱胺，谷胱甘肽，类胡萝卜素和许多其他抗氧化剂在色素沉着过度疾病中的作用。有很有希望的证据表明，这些抗氧化剂，作为局部，口服和静脉制剂，无论是在隔离和与其他黄褐斑疗法。
Melasma is a chronic dermatologic condition with an incompletely understood pathogenesis and well-demonstrated impact on patient quality of life. Melasma is a common cause for seeking dermatologic care, and with no universally efficacious therapy or cure, combination treatment is the best approach for many cases. Numerous studies have demonstrated the role of oxidative stress in patients with melasma, prompting investigation into several antioxidants for melasma therapy. In this review, we discuss the well-defined role of oxidative stress in melasma and the therapeutic efficacy of various antioxidants for patients suffering from melasma. We focus our discussion on studies investigating the role of vitamin C, azelaic acid, cysteamine, glutathione, carotenoids, and numerous other antioxidants in disorders of hyperpigmentation. There is promising evidence for the use of these antioxidants, as topical, oral, and intravenous preparations, both in isolation and in conjunction with other melasma therapies.