HDAC4: mechanism of regulation and biological functions.
HDAC4: mechanism of regulation and biological functions.
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DOI：
10.2217/epi.13.73
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发表时间：
2014-02
期刊：
影响因子：
3.8
通讯作者：
Zhao TC
中科院分区：
文献类型：
--
作者：
Wang Z;Qin G;Zhao TC
组蛋白的乙酰化和去乙酰化在基因转录调控中起重要作用。组蛋白乙酰化是由组蛋白乙酰转移酶（HAT）介导的。染色质结构的改变导致核小体松弛和转录激活的改变。逆反应由组蛋白脱乙酰酶（HDAC）介导，其诱导脱乙酰化、染色质凝聚和转录抑制。HDAC根据大小、序列同源性以及不同复合物的形成分为三个不同的类别，I、II和III。在II类HDAC中，HDAC 4涉及控制对多种细胞功能重要的基因表达。基础和临床实验证据已经充分证实HDAC4执行各种各样的功能。了解HDAC4的生物学意义不仅可以为HDAC4参与介导生物学反应的机制提供新的见解，而且还可以形成一个平台，以开发具有临床意义的治疗策略。
The acetylation and deacetylation of histones play an important role in the regulation of gene transcriptions. Histone acetylation is mediated by histone acetyltransferase (HAT). The resulting modification in the structure of chromatin leads to nucleosomal relaxation and altered transcriptional activation. The reverse reaction is mediated by histone deacetylase (HDAC), which induces deacetylation, chromatin condensation, and transcriptional repression. HDACs are divided into three distinct classes, I, II, and III, on the basis of size, sequence homology, as well as formation of distinct complexes. Among class II HDACs, HDAC4 is implicated in controlling gene expression important for diverse cellular functions. Basic and clinical experimental evidence have well established that HDAC4 performs a wide variety of functions. Understanding the biological significance of HDAC4 will not only provide new insight into the mechanisms of HDAC4 involved in mediating biological response, but also form a platform to develop a therapeutic strategy to achieve clinical implications.