Camptocormia treated with bilateral pallidal stimulation.
Camptocormia treated with bilateral pallidal stimulation.
复制标题
用双侧苍白球刺激治疗 Camptocormia。
作者：
D. Nandi;S. Parkin;R. Scott;J. Winter;C. Joint;R. Gregory;J. Stein;T. Aziz
作者报告了在1例致残性躯干弯曲病例中使用长期双侧苍白球高频脑深部电刺激（DBS）的神经学、神经生理学和神经心理学影响。立体定向植入脑深部刺激电极，靶向双侧苍白球内侧（GPi）。使用DBS电极记录局部场电位（FP），并在Campptocormic发作期间同时进行腹部屈肌肌电图（EMG）电位。记录植入前和开始苍白球刺激后6个月患者的运动障碍和神经心理学评价的录像评估。长期苍白球刺激后功能有明显改善，神经心理学评分也有一定改善。GPi FP和EMG记录的腹直肌电位之间的时间相关性是显而易见的。没有治疗相关的不良反应。作者发现，长期苍白球刺激是安全的，并为患有这种严重致残性疾病的患者提供了功能受益。生理学研究可能有助于进一步了解这种罕见的实体的病理生理。
The authors report the neurological, neurophysiological, and neuropsychological effects of using long-term bilateral pallidal high-frequency deep brain stimulation (DBS) in a case of disabling camptocormia. Deep brain stimulation electrodes were implanted stereotactically to target the globus pallidus internus (GPi) bilaterally. Local field potentials (FPs) were recorded using the DBS electrodes and concurrent abdominal flexor electromyography (EMG) potentials during camptocormic episodes. Videotaped assessments of the movement disorder and neuropsychological evaluations of the patient before implantation and 6 months after initiation of pallidal stimulation were recorded. There was significant functional improvement following long-term pallidal stimulation, and some improvement was noted in neuropsychological scores. A temporal correlation between the GPi FPs and EMG-recorded rectus abdominis potentials was evident. There were no treatment-related adverse effects. The authors have found that long-term pallidal stimulation was safe and offered functional benefit to a patient with this severely disabling condition. The physiological studies may help further the understanding of the pathophysiology of this rare entity.