SENSITIVITY ENHANCEMENTS OBTAINED AT HIGH-TEMPERATURES IN ATMOSPHERIC-PRESSURE IONIZATION MASS-SPECTROMETRY
SENSITIVITY ENHANCEMENTS OBTAINED AT HIGH-TEMPERATURES IN ATMOSPHERIC-PRESSURE IONIZATION MASS-SPECTROMETRY
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DOI：
10.1021/ac00164a013
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发表时间：
1988-07-01
影响因子：
7.4
通讯作者：
KEBARLE, P
中科院分区：
文献类型：
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作者：
SUNNER, J;IKONOMOU, MG;KEBARLE, P
研究了大气压电离质谱对大气中一系列分析物的灵敏度随离子源温度的变化关系。用SCIEX TAGA 6000E质谱仪在400 ℃下测定。许多硫基和碳基在室温下具有极低的灵敏度。随着样品的加热，许多这些分析物的灵敏度被发现增加了几个数量级，允许这些化合物的十亿分之一检测。相比之下，在室温下具有低灵敏度的氧碱仅显示出随着温度升高的小的灵敏度增加。对于那些在室温下具有非常高的灵敏度的分析物，主要是氮碱，也是这种情况。不同的灵敏度随温度变化的各种分析物可以预测的基础上的分析物气相碱度（GB）和质子化的分析物的气相水合的能量。
The sensitivity of atmospheric pressure ionization mass spectrometry to a range of analytes in atmospheric air was studied as a function of ion source temperature between 25 and ca. 400.degree.C with a SCIEX TAGA 6000E mass spectrometer. Many sulfur and carbon bases have extremely low sensitivities at room temperature. With the samples heated, the sensitivities of many of these analytes were found to increase by several orders of magnitude, allowing for sub-part-per-billion detection of these compounds. In contrast, oxygen bases with low sensitivity at room temperature show only small sensitivity increases with increasing temperature. This was also the case for those analytes, mostly nitrogen bases, that have very high sensitivity at room temperature. The different sensitivity changes with temperature for the various analytes can be predicted on the basis of the analyte gas-phase basicities (GB) and the energetics for the gas-phase hydration of the protonated analytes.