CLINICAL-RESULTS OF LONG-SURVIVING BRAIN-TUMOR PATIENTS WHO UNDERWENT BORON NEUTRON-CAPTURE THERAPY
CLINICAL-RESULTS OF LONG-SURVIVING BRAIN-TUMOR PATIENTS WHO UNDERWENT BORON NEUTRON-CAPTURE THERAPY
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DOI：
10.1016/0360-3016(94)90479-0
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发表时间：
1994-03-30
影响因子：
7
通讯作者：
NAKAGAWA, Y
中科院分区：
文献类型：
--
作者：
HATANAKA, H;NAKAGAWA, Y
目的：回顾分析硼中子俘获治疗恶性脑肿瘤患者的长期生存情况。方法与材料：截至1992年12月，120例脑内肿瘤和1例颅外神经相关肿瘤患者采用目前标准的硼中子俘获治疗技术进行治疗。1987年5月前手术的87例患者中，18例存活或已存活5年以上，均采用B-10-sodium-mercaptoundecahydrododecaborate.Results：治疗。在1982年5月之前接受手术的53名患者中，这18人中有9人的寿命超过了10西尔斯。在超过10年的幸存者中，只有两人在17岁和12岁时死亡。其他人都还活着。这两人死于延迟的辐射损伤，因为BNCT被应用于胶质母细胞瘤，这些肿瘤在他们的常规放射治疗后复发。他们死的时候没有肿瘤的证据。在这9名超过10年的幸存者中，有3人以前曾接受过常规的体外放射治疗，他们出现了辐射损伤，最终导致所有患者丧失能力。三人中有两人死亡。结论：BNCT是一种在不进行常规放射治疗的情况下，既能“治愈”良恶性脑肿瘤，又能保持良好生活质量的放射治疗方法。
Purpose: The present report is a review of long-term survivors in the patients with malignant brain tumors treated by boron neutron capture therapy.Methods and Material: One-hundred twenty patients with 119 intracranial tumors and one extracranial nerve-related tumor were treated by the current standard technique of boron-neutron capture therapy (BNCT) as of December 1992, using B-10-sodium-mercaptoundecahydrododecaborate.Results: Out of 87 patients operated on before May 1987, 18 lived or have lived longer than 5 years. Nine of these 18 lived or have lived longer than 10 Sears out of 53 patients operated on before May 1982. Among more-than-10-year survivors, only two died at 17 and 12 years. All of the other are still alive. The two died of delayed radiation damage because BNCT was applied to glioblastomas which recurred after their conventional radiotherapy. They lacked evidence of tumors when they died. Out of these nine more-than-10-year survivors, three had been previously treated by conventional external radiotherapy and they developed radiation damage which brought all patients ultimately to an incapacitated condition. Two of the three died. All the other 6 who were free from previous radiation history are active in their jobs and have no evidence of tumors.Conclusion: It can be suggested that BNCT is a radiotherapy that can produce ''cure'' of both malignant and benign brain tumors while preserving a good quality of life if conducted without conventional radiotherapy.