PRIMARY LIVER CANCERS IN JAPAN
PRIMARY LIVER CANCERS IN JAPAN
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DOI：
10.1002/1097-0142(19800515)45:10
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发表时间：
1980-01-01
期刊：
影响因子：
6.2
通讯作者：
OKUDA, K
中科院分区：
文献类型：
--
作者：
OKUDA, K
本文对1968年1月1日至1977年12月31日在155个单位诊断的4031例原发性肝癌进行了问卷调查，并作了统计分析。其中肝细胞癌2411例，胆管细胞癌268例，混合型58例，肝母细胞瘤69例，其他23例，仅临床诊断1202例。主要基于组织学证实的病例的调查和分析包括肿瘤的大体解剖和组织学特征、肿瘤细胞的间变分级和生长模式、非癌肝部分的病理、伴随的肝硬化或纤维化的频率、远处转移、既往史、既往史中肝炎的频率、HBsAg [肝炎B表面抗原]和抗-HBs阳性的频率，阳性HBsAg测试的家族聚集性、年龄分布、主观症状、客观体征、血清α-甲胎蛋白、腹腔血管造影结果、手术次数、手术入路类型、肝切除程度、与各种手术治疗相关的生存预后、使用的化疗药物和给药途径、与伴随的实质性肝病相关的预后和总生存率。
Statistical analyses were made of 4031 cases of primary liver cancers diagnosed at 155 institutes during the period of Jan. 1, 1968-Dec. 31, 1977, based on a questionnaire. There were 2411 cases of hepatocellular carcinoma, 268 of cholangiocellular carcinoma, 58 of the mixed type, 69 of hepatoblastoma, 23 of others and 1202 cases with only clinical diagnosis. The survey and analyses mostly based on the histology-proven cases included gross anatomical and histological features of tumors, grades of anaplasia and growth patterns of tumor cells, pathology of noncancerous liver portion, frequency of accompanying cirrhosis or fibrosis, distant metastases, past history, frequency of hepatitis in the past history, frequency of positive HBsAg [hepatitis B surface antigen] and anti-HBs, familial clustering of positive HBsAg tests, age distribution, subjective symptoms, objective signs, serum .alpha.-fetoprotein, celiac angiography findings, number of operations performed, kinds of surgical approaches made, extents of hepatic resection, prognosis in terms of survival in relation to various surgical treatments, chemotherapeutic agents used and routes of administration, prognosis as related to the accompanying parenchymal liver disease and overall survival.