An update on lipotoxic endoplasmic reticulum stress in pancreatic β-cells
An update on lipotoxic endoplasmic reticulum stress in pancreatic β-cells
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DOI：
10.1042/bst0360909
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发表时间：
2008-10-01
影响因子：
3.9
通讯作者：
Eizirik, Decio L.
中科院分区：
文献类型：
--
作者：
Cnop, Miriam;Igoillo-Esteve, Mariana;Eizirik, Decio L.
未折叠蛋白反应(OR)或内质网(ER)应激反应在20年前首次被描述。自那以后，内质网应激的领域已经大大扩大，从酵母中的基础生物学发展到人类神经退行性疾病、炎症、心血管疾病和肿瘤。内质网应激反应也与糖尿病的发生有关，影响胰岛β细胞的胰岛素分泌和外周组织的胰岛素敏感性。在这篇简短的综述中，我们重点介绍了胰岛β细胞内质网应激领域的最新进展。讨论了脂毒性内质网应激和p细胞从内质网应激中恢复的最新进展。
The OR (unfolded protein response) or ER (endoplasmic reticulum) stress response was first described 20 years ago. The field of ER stress has expanded tremendously since, moving from basic biology in yeast to human neurodegenerative, inflammatory, cardiovascular and neoplastic diseases. The ER stress response has also been implicated in diabetes development, affecting both insulin production by pancreatic beta-cells and insulin sensitivity in peripheral tissues. In the present mini-review, we focus on recent progress in the field of ER stress in pancreatic beta-cells. Recent advances in the understanding of lipotoxic ER stress and p-cell recovery from ER stress are discussed.