Vascular protective effects of Angiotensin Receptor Blockers: Beyond Blood pressure.
Vascular protective effects of Angiotensin Receptor Blockers: Beyond Blood pressure.
复制标题
DOI：
10.14800/rci.774
复制
发表时间：
2015-04
期刊：
影响因子：
--
通讯作者：
S. Artham;A. Fouda;A. El-Remessy;S. Fagan
中科院分区：
文献类型：
--
作者：
S. Artham;A. Fouda;A. El-Remessy;S. Fagan
AT 1 R阻滞剂（ARB）是一种主要的降压药物。它们被认为是原发性高血压的一线治疗。此外，ARB是其他心血管疾病的基石治疗方法，尤其是对于患有糖尿病和肾脏合并症的患者。临床和实验证据证明ARB的有益作用超出了降血压作用。缺血性疾病如中风和增殖性视网膜病变的特征在于缺氧驱动的血管生成生长因子的释放[2]。然而，缺血区域的血运重建不充分，导致神经血管功能受损。ARB已显示出血管保护和促或抗血管生成作用，具体取决于研究中的组织/细胞类型和疾病状况[3]。我们的研究小组已经证明了ARB和坎地沙坦的血管保护作用，特别是在缺血性中风和视网膜病变模型中。坎地沙坦的积极影响主要是通过增强促血管生成状态和刺激修复性血管生成。本评论旨在强调最近发现的途径，直接阻断AT 1受体或间接通过可能激活AT 2受体的背景下发表的文献。
AT1R blockers (ARBs) represent a major class of antihypertensive medications. They are considered first line treatment for essential hypertension. Moreover, ARBs are the cornerstone treatment for other cardiovascular diseases especially in patients with diabetic and renal comorbidities. Clinical and experimental evidence have documented the beneficial actions of ARBs beyond the blood pressure lowering effect. Ischemic diseases such as stroke and proliferative retinopathy are characterized by hypoxia-driven release of angiogenic growth factors [2] . However, revascularization of the ischemic areas is inadequate, resulting in impaired neuro-vascular function. ARBs have been shown to exhibit vascular protective and pro- or anti-angiogenic effects depending on the tissue/cell type and disease condition under study [3] . Our group has demonstrated the vascular protective effects of ARBs and candesartan, in particular, in models of ischemic stroke and retinopathy. The positive impact of candesartan was mainly via enhancing the proangiogenic state and stimulation of reparative angiogenesis. This commentary aims to highlight the recently identified pathways that took place as result of directly blocking AT1 receptor or indirectly by possible activation of AT2 receptor in the context of the published literature.