Blood levels of TT virus following immune stimulation with influenza or hepatitis B vaccine
Blood levels of TT virus following immune stimulation with influenza or hepatitis B vaccine
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DOI：
10.1002/jmv.20278
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发表时间：
2005-02-01
影响因子：
12.7
通讯作者：
Bendinelli, M
中科院分区：
文献类型：
--
作者：
Maggi, F;Tempestini, E;Bendinelli, M
Torque Teno 病毒 (TTV) 已被证明持续存在于健康个体的血液中，但没有证据表明它会导致任何疾病过程。在同时感染其他病毒的患者中，TTV 的水平有所不同，并且对于 TTV 是否有助于其他病毒的发病机制，或者不同的水平是否可能与宿主的免疫激活有关，人们有相当多的猜测。在本研究中，在用流感（一种回忆抗原）或乙型肝炎病毒（HBV）（一种新的抗原暴露）对受试者进行免疫接种后，检查了血浆和外周血单核细胞（PBMC）中TTV的负载。总体结果表明，在 90 天的观察期内，TTV 滴度没有发生显着变化；然而，当考虑到 TTV 基因组时，持续感染基因组 3 的受试者在某些时间点血浆中的病毒载量会增加。虽然在流感和 HBV 免疫受试者中都观察到了这种情况，但在 HBV 疫苗接种中效果更为深远。因此，看来暴露于新抗原而不是回忆抗原可能更有效地刺激TTV复制。数据进一步表明，研究 TTV 与其宿主之间的相互作用可能需要分别专门检查每个 TTV 基因组，以确定某些 TTV 类型是否在疾病发病机制中发挥作用。 (C) 2004 Wiley-Liss, Inc.
Torque Teno virus (TTV) has been demonstrated to be present persistently in the blood of healthy individuals without evidence that it causes any disease process. The levels of TTV vary in patients co-infected with other viruses and there has been considerable speculation as to whether TTV contributes to pathogenesis by other viruses or if the varying levels might be related to immune activation in the host. In the present study, the load of TTV was examined in plasma and peripheral blood mononuclear cells (PBMCs) following immunization of subjects with either influenza (a recall antigen) or hepatitis B virus (HBV) (a new antigenic exposure). The results overall did not indicate a significant change in TTV titers over a 90 day observation period; however, when TTV genogroup was taken into consideration there was an increase in viral load in plasma at some time points for subjects persistently infected with genogroup 3. While this was observed in both influenza and HBV immunized subjects, the effect was more profound in HBV vaccination. Thus, it appears that exposure to a new antigen rather than a recall antigen may stimulate TTV replication more effectively. The data further suggest that investigating the interactions between TTV and its host might require to examine specifically each TTV genogroup separately in order to determine if certain TTV types have any role in disease pathogenesis. (C) 2004 Wiley-Liss, Inc.