Maternal Fever During Early Pregnancy and the Risk of Oral Clefts
Maternal Fever During Early Pregnancy and the Risk of Oral Clefts
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DOI：
10.1002/bdra.20646
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发表时间：
2010-03-01
影响因子：
--
通讯作者：
Hecht, Jacqueline T.
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文献类型：
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作者：
Hashmi, S. Shahrukh;Gallaway, M. Shayne;Hecht, Jacqueline T.
在动物研究中证实了高温暴露后出生缺陷的风险增加，但人口研究得出了不一致的结果。唇裂是一种常见的出生缺陷，在其中一些研究中与这些暴露有关。在这项研究中，来自国家出生缺陷预防研究的数据被用来评估母亲在怀孕早期报告发热性疾病与唇腭裂风险之间的关系。研究人员将1997年至2004年出生的所有唇裂病例与同期出生在同一地理区域的非畸形对照进行了比较。母亲在怀孕期间报告发热性疾病分层的发热等级和解热药的使用。Logistic回归模型用于生成暴露于发热和与每种口裂表型相关的粗比值比和校正比值比。该数据集包括5821名对照，1567例唇腭裂或腭裂（CL+/-P）和835例腭裂。观察到孤立CL+/-P的风险适度增加（比值比，1.28; 95%置信区间，1.01-1.63）。按发热等级（体温= 101.5华氏度）分层，风险没有显著差异。报告发烧但未服用退烧药控制发烧的妇女的风险估计值较高，特别是与孤立的唇腭裂相比，非孤立的唇腭裂。这一发现表明，适当的控制发烧可能会减少发烧的有害影响的情况下，口裂。出生缺陷研究（A部分）88：186-194，2010年。(C)2010 Wiley-Liss，Inc.
An increased risk of birth defects after hyperthermic exposures has been confirmed in animal studies, but population studies have yielded inconsistent results. Oral clefts are a common birth defect and have been associated with these exposures in some of these studies. In this study, data from the National Birth Defects Prevention Study was used to evaluate the association of maternal report of febrile illness in early pregnancy and the risk of oral clefts. All oral cleft cases born between 1997 and 2004 were compared with nonmalformed controls born in the same geographical region during the same time period. Mothers reporting febrile illness during pregnancy were stratified by fever grade and antipyretic use. Logistic regression models were used to generate crude and adjusted odds ratios for exposure to fever and association with each oral cleft phenotype. The data-set included 5821 controls, 1567 cases of cleft lip with or without cleft palate (CL+/-P) and 835 cases of cleft palate only. A modestly increased risk was observed for isolated CL+/-P (odds ratio, 1.28; 95% confidence interval, 1.01-1.63). Stratification by fever grade (body temperature = 101.5 degrees F) did not yield significant differences in risk. Risk estimates were higher among women who reported a fever, but did not take antipyretics to control their fever, particularly for nonisolated compared with isolated oral clefts. This finding suggests that adequate control of fever may diminish the deleterious effects of fever in cases of oral cleft. Birth Defects Research (Part A) 88:186-194, 2010. (C) 2010 Wiley-Liss, Inc.