Collagen degradation in rat skin but not in intestine during rapid growth: effect on collagen types I and III from skin.
Collagen degradation in rat skin but not in intestine during rapid growth: effect on collagen types I and III from skin.
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在快速生长过程中，大鼠皮肤中的胶原蛋白降解，但肠道中的胶原蛋白不降解：对皮肤中 I 型和 III 型胶原蛋白的影响。
DOI：
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发表时间：
1977
影响因子：
11.1
通讯作者：
J. Chandrarajan
中科院分区：
文献类型：
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作者：
L. Klein;J. Chandrarajan
全身皮肤和整个肠道中的预标记胶原蛋白的代谢降解进行了比较，从年轻，快速生长的大鼠皮肤的I型和III型胶原蛋白。妊娠大鼠在妊娠的最后一周给予[3 H]脯氨酸;出生后，对同窝仔进行比较。在第二和第六周龄之间，真皮胶原蛋白的放射性损失为43%，但肠胶原蛋白的放射性没有显著损失。胃蛋白酶处理溶解了90%的真皮胶原蛋白，但仅溶解了12%的肠胶原蛋白。2周龄和6周龄大鼠的皮肤产生了相同比例的I型和III型胶原（I型，82%; III型，18%）。I型和III型的总放射性相对损失彼此相似（分别为50%和44%），并且与整个皮肤的损失相似。因为已知I型和III型胶原蛋白存在于皮肤和肠中，所以皮肤中而非肠中的两种胶原蛋白类型的显著降解可能与存在的分子间交联的量和种类有关。
Metabolic degradation of prelabeled collagen in whole body skin and whole intestine was compared to that of types I and III collagens from skin in young, rapidly growing rats. Pregnant rats were given [3H]proline during the last week of gestation; and after birth, littermates were compared. Between the second and sixth weeks of age, there was a 43% loss of radioactivity from dermal collagen but no significant loss of radioactivity from intestinal collagen. Pepsin treatment solubilized 90% of the dermal collagen but only 12% of intestinal collagen. Skin from 2- and 6-week-old rats yielded the same proportions of type I and type III collagens (type I, 82%; type III, 18%). The relative losses of total radioactivity from types I and III were similar to each other (50 and 44%, respectively) and to the loss from whole skin. Because types I and III collagens are known to be present in both skin and intestine, the marked degradation of both collagen types in skin but not in the intestine may be related to the amount and kind of intermolecular crosslinks present.