The impact of plasma brain-derived neurotrophic factor concentration and weight gain after kidney transplantation.
The impact of plasma brain-derived neurotrophic factor concentration and weight gain after kidney transplantation.
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肾移植后血浆脑源性神经营养因子浓度和体重增加的影响。
DOI：
10.1002/nur.21921
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发表时间：
2019
影响因子：
2
通讯作者：
Cashion,AnnK
中科院分区：
文献类型：
--
作者：
Lai,Chen;Stanfill,AnsleyG;Zhang,Xuemin;Cashion,AnnK
肥胖及其相关并发症仍然是肾移植受者面临的重大挑战。在以前的研究中，研究人员报道脑源性神经营养因子（BDNF）与代谢失衡和肥胖密切相关，但BDNF在肾移植后体重增加中的作用尚未阐明。本研究旨在探讨血浆BDNF水平与体重变化的关系。我们研究了移植时和12个月后测量的血浆BDNF水平与这12个月内55名肾移植受者（平均年龄48岁，60%男性，56%非裔美国人）的体重变化之间的相关性。在55名接受者中，49名在基线时测量了BDNF水平，33名在12个月时测量了BDNF水平，27名在两个时间点测量了BDNF水平。我们发现，血浆BDNF水平在基线（n= 49），但不是在12个月（n= 33），与体重指数变化（p= 0.037）和体重变化百分比（p= 0.036）显着正相关。此外，在12个月时的平均血浆BDNF值（307 ± 254 pg/ml）显著低于基线（452 ± 345 pg/ml），在两个时间点测量了BDNF水平。这项试点工作的结果表明，BDNF可能作为肾移植相关肥胖的体重变化的调节剂。
Obesity and its related complications continue to be significant challenges for kidney transplant recipients. In previous studies, researchers have reported that brain‐derived neurotrophic factor (BDNF) is closely associated with metabolic imbalance and obesity, but the role of BDNF in weight gain after kidney transplant has not been elucidated. The purpose of this pilot study was to explore the relationship between plasma BDNF levels and weight change. We examined associations between plasma BDNF levels measured at transplantation and 12 months later and measures of weight change during these 12 months in a sample of 55 kidney recipients (mean age of 48 years, 60% male, 56% African American). Of the 55 recipients, 49 had BDNF levels measured at baseline, 33 had BDNF levels measured at 12 months, and 27 had BDNF levels measured at both time points. We found that plasma BDNF levels at baseline (n= 49), but not at 12 months (n= 33), were significantly and positively correlated with the body mass index change (p= 0.037) and percentage weight change (p= 0.036). In addition, average plasma BDNF value at 12 months (307 ± 254 pg/ml) was significantly lower than at baseline (452 ± 345 pg/ml) in the 27 recipients with BDNF levels measured at both time points. Findings from this pilot work suggest that BDNF might serve as a regulator of weight change for kidney transplant related obesity.