Macrocycle-derived functional xanthenes and progress towards concurrent detection of glucose and fructose.
Macrocycle-derived functional xanthenes and progress towards concurrent detection of glucose and fructose.
复制标题
大环衍生的功能性呫吨以及同时检测葡萄糖和果糖的进展。
DOI：
10.1023/b:jofl.0000039348.74270.03
复制
发表时间：
2004
影响因子：
2.7
通讯作者：
Strongin,RobertM
中科院分区：
文献类型：
--
作者：
Rusin,Oleksandr;Alpturk,Onur;He,Ming;Escobedo,JorgeO;Jiang,Shan;Dawan,Fareed;Lian,Kun;McCarroll,MatthewE;Warner,IsiahM;Strongin,RobertM
检测生物介质中的微生物对于监测疾病状态具有重要的现实意义。我们以前曾报道过，硼酸官能化的大环化合物的溶液原位形成无环低聚材料。低聚物含有荧光咕吨部分。目前的努力旨在调节这些材料的光谱响应，用于分析特定的糖。我们描述了氧杂蒽硼酸表现出高比色果糖选择性的条件。相比之下，在生理水平下，可以通过荧光实现选择性葡萄糖监测。此外，我们描述了一种有望在紫外-可见光区域的双波长下检测葡萄糖和果糖的方法。提出了这些发现的机制依据。
The detection of saccharides in biological media is of great current importance for the monitoring of disease states. We have previously reported that solutions of boronic acid-functionalized macrocycles form acyclic oligomeric materialsin situ. The oligomers contain fluorescent xanthene moieties. Current efforts are aimed at modulating the spectroscopic responses of these materials for the analysis of specific sugars. We describe conditions whereby the xanthene boronic acids exhibit high colorimetric fructose selectivity. In contrast, at physiological levels selective glucose monitoring can be achieved via fluorescence. Additionally, we describe a method which exhibits promise for detecting both glucose and fructose at dual wavelengths in the UV-Vis region. Mechanistic rationale for each of these findings is presented.