New translational assays for preclinical modelling of cognition in schizophrenia: the touchscreen testing method for mice and rats.
New translational assays for preclinical modelling of cognition in schizophrenia: the touchscreen testing method for mice and rats.
复制标题
精神分裂症认知临床前模型的新转化测定：小鼠和大鼠的触摸屏测试方法。
DOI：
10.1016/j.neuropharm.2011.04.011
复制
发表时间：
2012-03
影响因子：
4.7
通讯作者：
Saksida LM
中科院分区：
文献类型：
--
作者：
Bussey TJ;Holmes A;Lyon L;Mar AC;McAllister KA;Nithianantharajah J;Oomen CA;Saksida LM
我们描述了一种触摸屏方法，该方法满足了为评估精神分裂症啮齿动物模型的认知测试方法所提出的理想“愿望清单”。描述了一些与精神分裂症研究相关的测试，目前正在使用这种方法进行开发和验证。这些测试可用于研究奖励学习、记忆、知觉辨别、物体 - 位置联想学习、注意力、冲动性、强迫性、消退、简单的巴甫洛夫条件反射以及其他构想。可以使用“灵活组合”的方法来部署这些测试，以便为特定的小鼠或大鼠模型建立认知特征。我们发现这些测试不仅能够检测功能的损伤，还能检测功能的增强，这对于测试假定的认知疗法至关重要。新的测试正在不断开发，其中许多可能对精神分裂症研究特别有价值。
We describe a touchscreen method that satisfies a proposed ‘wish-list’ of desirables for a cognitive testing method for assessing rodent models of schizophrenia. A number of tests relevant to schizophrenia research are described which are currently being developed and validated using this method. These tests can be used to study reward learning, memory, perceptual discrimination, object-place associative learning, attention, impulsivity, compulsivity, extinction, simple Pavlovian conditioning, and other constructs. The tests can be deployed using a ‘flexible battery’ approach to establish a cognitive profile for a particular mouse or rat model. We have found these tests to be capable of detecting not just impairments in function, but enhancements as well, which is essential for testing putative cognitive therapies. New tests are being continuously developed, many of which may prove particularly valuable for schizophrenia research.