Does telomere length mediate associations between inbreeding and increased risk for bipolar I disorder and schizophrenia?
Does telomere length mediate associations between inbreeding and increased risk for bipolar I disorder and schizophrenia?
复制标题
DOI：
10.1016/j.psychres.2011.01.010
复制
发表时间：
2011-06-30
影响因子：
11.3
通讯作者：
Nimgaonkar, Vishwajit L.
中科院分区：
文献类型：
--
作者：
Mansour, Hader;Chowdari, Kodavali;Nimgaonkar, Vishwajit L.
我们最近发现，在埃及，血缘关系是双相I型障碍（BP 1）和精神分裂症（SZ）的一个危险因素。近亲繁殖与植物和动物中增加的细胞压力和受损的生理功能有关。以前的研究已经报道，端粒长度（TL），氧化应激和细胞衰老的指数显着减少与SZ或情绪障碍患者与对照组相比。因此，我们评估了TL作为一个可能的调解员之间观察到的关联血缘关系和BP 1/SZ风险。在单独的实验中，将患有BP 1（n = 108）或SZ（n = 60）的患者与筛选的成人对照进行比较。使用基于定量PCR（qPCR）的测定来估计TL。近亲繁殖系数/近亲繁殖率的估计有两种方法：使用64个DNA多态性（“DNA为基础的”率），并从家族史数据（“自我报告”）。TL和基于DNA的近亲繁殖之间的显着相关性没有观察到的整体，虽然提示的趋势之间存在SZ的情况下。在控制人口统计学变量后，没有发现TL的显著病例对照差异。总之，减少TL可能无法解释一个显着比例的近亲和风险BP 1/SZ之间观察到的关联。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
We have recently found that consanguinity is a risk factor for bipolar I disorder (BP1) and schizophrenia (SZ) in Egypt. Inbreeding has been associated with increased cellular stress and impaired physiological function in plants and animals. Previous studies have reported that telomere length (TL), an index of oxidative stress and cellular senescence is significantly reduced among patients with SZ or mood disorders compared with control individuals. Hence we evaluated TL as a possible mediator of the observed association between consanguinity and BP1/SZ risk. Patients with BP1 (n = 108), or SZ (n = 60) were compared with screened adult controls in separate experiments. TL was estimated using a quantitative PCR (qPCR) based assay. The inbreeding coefficient/consanguinity rate was estimated in two ways: using 64 DNA polymorphisms ('DNA-based' rate); and from family history data ('self report'). Significant correlation between TL and DNA based inbreeding was not observed overall, though suggestive trends were present among the SZ cases. No significant case-control differences in TL were found after controlling for demographic variables. In conclusion, reduced TL may not explain a significant proportion of observed associations between consanguinity and risk for BP1/SZ. (C) 2011 Elsevier Ireland Ltd. All rights reserved.