A multicenter randomized controlled trial of two group education programs for fatigue in multiple sclerosis: Long-term (12-month) follow-up at one site
A multicenter randomized controlled trial of two group education programs for fatigue in multiple sclerosis: Long-term (12-month) follow-up at one site
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DOI：
10.1177/1352458518775920
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发表时间：
2019-05-01
影响因子：
5.8
通讯作者：
Bourdette, Dennis
中科院分区：
文献类型：
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作者：
Hugos, Cinda L.;Cameron, Michelle H.;Bourdette, Dennis
背景：在为期6个月的修订疲劳影响量表(MFIS)上，一项多组分的四点疲劳控制RCT(FTC)与控制程序MS：Take Control(MSTC)在疲劳方面没有发现显著差异。目的：评估FTC对疲劳的延迟效应。方法：在同一地点的78名受试者中，74名被随机分配到FTC或MSTC的受试者在12个月后完成了MFIS。结果：与基线相比，12个月时，FTC组MFIS评分的改善显著高于MSTC组(FTC-8.9(可信区间：32.2，45)，MSTC-2.5(CI：39.6，47.7)，p=0.03)。结论：FTC对疲劳的延迟效应表明，在评估疲劳干预措施时，需要更长的随访时间。
Background: A four-site RCT of Fatigue: Take Control (FTC), a multicomponent group program, found no significant differences from a control program, MS: Take Control (MSTC), in fatigue on the Modified Fatigue Impact Scale (MFIS) through 6 months. Objective: Assess FTC for a delayed effect on fatigue. Methods: Of 78 subjects at one site, 74 randomized to FTC or MSTC completed the MFIS at 12 months. Results: Compared to baseline, FTC produced greater improvements in MFIS scores than MSTC (FTC -8.9 (confidence interval (CI): 32.2, 45), MSTC -2.5 (CI 39.6, 47.7), p = 0.03) at 12 months. Conclusion: The delayed effect of FTC on fatigue suggests the need for longer follow-up when assessing interventions for fatigue.