Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome.
Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome.
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DOI：
10.1016/j.cell.2020.08.007
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发表时间：
2020-09-17
期刊：
影响因子：
64.5
通讯作者：
Kashyap PC
中科院分区：
文献类型：
--
作者：
Mars RAT;Yang Y;Ward T;Houtti M;Priya S;Lekatz HR;Tang X;Sun Z;Kalari KR;Korem T;Bhattarai Y;Zheng T;Bar N;Frost G;Johnson AJ;van Treuren W;Han S;Ordog T;Grover M;Sonnenburg J;D'Amato M;Camilleri M;Elinav E;Segal E;Blekhman R;Farrugia G;Swann JR;Knights D;Kashyap PC
肠道微生物群与多种人类慢性胃肠道(GI)疾病有关。由于动物和人类研究之间的明显脱节，以及缺乏对疾病特定生理变化的综合多组学观点，确定其在疾病中的机制作用一直是困难的。在肠易激综合征(IBS)宿主生理学的背景下，我们整合了来自肠道微生物组、代谢组、宿主表观基因组和转录组的纵向多组学数据。我们确定了IBS在微生物组成和功能上的亚型特异性和症状相关变异。已识别的微生物代谢物变化的子集对应于与IBS相关的宿主生理机制。通过整合多个数据层，我们确定嘌呤代谢是IBS中一种新的宿主-微生物代谢途径，具有翻译潜力。我们的研究强调了纵向抽样和整合互补的多组学数据的重要性，以确定可作为慢性胃肠道疾病综合治疗策略的治疗靶点的功能机制。对肠易激综合征患者的综合和纵向多组学分析揭示了肠道微生物区系在调节嘌呤代谢和影响宿主胃肠功能方面的作用。
The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiological changes. We integrated longitudinal multi-omics data from the gut microbiome, metabolome, host epigenome, and transcriptome in the context of irritable bowel syndrome (IBS) host physiology. We identified IBS subtype-specific and symptom-related variation in microbial composition and function. A subset of identified changes in microbial metabolites correspond to host physiological mechanisms that are relevant to IBS. By integrating multiple data layers, we identified purine metabolism as a novel host-microbial metabolic pathway in IBS with translational potential. Our study highlights the importance of longitudinal sampling and integrating complementary multi-omics data to identify functional mechanisms that can serve as therapeutic targets in a comprehensive treatment strategy for chronic GI diseases. Integrated and longitudinal multiomic analyses of patients with irritable bowel syndrome reveals a role for the gut microbiota in modulating purine metabolism and influencing host gastrointestinal function.
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有症状性神经源性体性低血压患者的随机戒断研究反应了龙氧化疾病。
DOI：
10.1161/hypertensionaha.114.04035
发表时间：
2015-01
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
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影响因子：
6.4
作者：
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通讯作者：
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影响因子：
17.1
作者：
De Palma, Giada;Lynch, Michael D. J.;Bercik, Premysl
通讯作者：
Bercik, Premysl
影响因子：
4.8
作者：
Lee, J. Scott;Wang, Ruth X.;Colgan, Sean P.
通讯作者：
Colgan, Sean P.
影响因子：
12.3
作者：
Kim D;Pertea G;Trapnell C;Pimentel H;Kelley R;Salzberg SL
通讯作者：
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