The prevalence of atrial fibrillation in a geographically well-defined population in Northern Sweden: implications for anticoagulation prophylaxis
The prevalence of atrial fibrillation in a geographically well-defined population in Northern Sweden: implications for anticoagulation prophylaxis
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DOI：
10.1111/j.1365-2796.2012.02519.x
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发表时间：
2012-08-01
影响因子：
11.1
通讯作者：
Terent, A.
中科院分区：
文献类型：
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作者：
Andersson, P.;Londahl, M.;Terent, A.
。Andersson P, Londahl M, Abdon N-J, Terent A （Hudiksvall医院，Hudiksvall； Lund大学，Lund； Uppsala大学，Uppsala；瑞典）。在瑞典北部一个地理上定义明确的人群中房颤的患病率：抗凝预防的意义。实习医学杂志2012；272: 170176。目标。本研究的目的是评估西方社会以社区为基础的房颤（AF）患病率，以瑞典北部地理位置明确的人群为参考，并根据卒中风险指数CHADS2和CHA2DS2-VASc估计适合口服抗凝（OAC）预防治疗的患者比例。出血风险采用ha - bled评分进行评估。设计。研究人群从AURICULA招募，AURICULA是瑞典接受抗凝治疗的患者的国家质量登记。所有集水区诊断为房颤的患者均在AURICULA中登记。结果。在集水区65532名居民中，1616人被诊断为房颤（1200例为慢性房颤）。因此，AF的总患病率为2.5%。患病率随年龄增长而增加，55岁以上患者为6.3%，80岁以上患者为13.8%。在所有年龄组中，男性的患病率都高于女性。总体而言，根据CHADS2和CHA2DS2-VASc， 56.3%和85.1%的人群分别处于卒中高风险（=2分）。此外，根据HAS-BLED， 26.9%的患者出血风险增加。结论。在这个庞大的高加索人群中，我们确定了迄今为止最高的AF社区患病率。患病率与年龄增长和男性性别密切相关。使用CHA2DS2-VASc代替CHADS2扩大了OAC预防治疗房颤的适应症。
. Andersson P, Londahl M, Abdon N-J, Terent A (Hudiksvall Hospital, Hudiksvall; Lund University, Lund; and Uppsala University, Uppsala; Sweden). The prevalence of atrial fibrillation in a geographically well-defined population in Northern Sweden: implications for anticoagulation prophylaxis. J Intern Med 2012; 272: 170176. Objectives. The aims of this study were to evaluate the community-based prevalence of atrial fibrillation (AF) in a western society using a geographically well-defined population in the northern part of Sweden as a reference and to estimate the proportion of patients eligible for oral anticoagulation (OAC) prophylactic therapy according to the stroke risk indices CHADS2 and CHA2DS2-VASc. Bleeding risk was assessed using the HAS-BLED score. Design. The study population was recruited from AURICULA, a Swedish national quality register for patients receiving anticoagulation treatment. All patients with the diagnosis AF in the catchment area are registered in AURICULA. Results. Of the 65 532 inhabitants in the catchment area, 1616 were diagnosed with AF (1200 cases were characterized as chronic AF). Thus, the overall prevalence of AF was 2.5%. The prevalence increased with age from 6.3% in patients over 55 years of age to 13.8% in those over 80 years. The prevalence was higher in men than in women in all age groups. Overall, 56.3% and 85.1% of the population were at high risk of stroke (=2 points) according to CHADS2 and CHA2DS2-VASc, respectively. In addition, 26.9% had an increased bleeding risk according to HAS-BLED. Conclusion. Within this large Caucasian population, we identified the highest community-based prevalence of AF to date. The prevalence was strongly associated with increasing age and male gender. Using CHA2DS2-VASc instead of CHADS2 widened the indication for OAC prophylactic therapy of AF in this population.