Initial interactions of subgenus D adenoviruses with a549 cellular receptors:: Sialic acid versus αv integrins
Initial interactions of subgenus D adenoviruses with a549 cellular receptors:: Sialic acid versus αv integrins
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DOI：
10.1128/jvi.74.16.7691-7693.2000
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发表时间：
2000-08-01
影响因子：
5.4
通讯作者：
Wadell, G
中科院分区：
文献类型：
--
作者：
Arnberg, N;Kidd, AH;Wadell, G
已显示腺病毒家族的选定成员与靶细胞上科萨基腺病毒受体或整合素和唾液酸相互作用。亚属D腺病毒与靶细胞的初始相互作用迄今为止还没有得到很好的表征。在这里，我们证明了8型腺病毒（Ad8），Ad19a和Ad37使用唾液酸作为功能性细胞受体，而Ad9和Ad19原型没有。
Selected members of the adenovirus family have been shown to interact with the coxsackie adenovirus receptor, or, integrins, and sialic acid on target cells. Initial interactions of subgenus D adenoviruses with target cells have until now been poorly characterized. Here, we demonstrate that adenovirus type 8 (Ad8), Ad19a, and Ad37 use sialic acid as a functional cellular receptor, whereas the Ad9 and Ad19 prototypes do not.