Executive function and relation to static balance metrics in chronic mild TBI: A LIMBIC-CENC secondary analysis.
Executive function and relation to static balance metrics in chronic mild TBI: A LIMBIC-CENC secondary analysis.
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慢性轻度TBI中的执行功能和与静态平衡指标的关系：边缘阵容二级分析。
DOI：
10.3389/fneur.2022.906661
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发表时间：
2022
影响因子：
3.4
通讯作者：
Walker, William C.
中科院分区：
文献类型：
--
作者：
van der Veen, Susanne M.;Perera, Robert A.;Manning-Franke, Laura;Agyemang, Amma A.;Skop, Karen;Sponheim, Scott R.;Wilde, Elisabeth A.;Stamenkovic, Alexander;Thomas, James S.;Walker, William C.
在患有创伤性脑损伤（TBI）的患者中，姿势不稳定通常长期持续，具有负面后果，例如较高的跌倒风险。一种解释可能是有效处理、解释和联合收割机、感觉信息所需的执行功能（EF）降低。在其他人群中，高级认知功能的下降与行走和平衡技能的下降有关。考虑到EF下降和功能能力下降之间的联系，我们调查了执行功能的特定测试是否可以预测具有慢性轻度TBI（mTBI）史的个体的队列中的平衡功能，并与具有阴性mTBI史的个体进行比较。对当地LIMBIC-CENC队列（N = 338，259 mTBI，平均45 ± STD 10岁）进行次要分析。静态平衡用感觉组织测试（SOT）评估。使用以下模块对每个EF测试结果进行分层回归：（1）持续TBI的数量，年龄和性别;（2）单独的连线测试（TMT）;（3）抗扫视眼动跟踪项目（4）PZ和FZ反应时的Oddball分心刺激P300和N200;（5）奇数靶刺激P300和N200的PZ和FZ反应。具有所有预测因子的完整模型占平衡测量的变异性的15.2%至21.5%。TBI的数量与SOT 2评分呈负相关（p = 0.002）。此外，完成TMT部分B的时间较长与SOT 1评分较差相关（p = 0.038）。EEG干扰物对SOT 3评分的影响最大（p = 0.019）。最后，SOT复合和SOT 5评分显示与较长的抑制潜伏期和错误相关（抗扫视潜伏期和错误，分别为p = 0.026和p = 0.043）。这些发现表明，当视觉被遮挡或损坏时，感觉输入的整合和重新加权与EF最相关。这表明，战斗暴露的退伍军人和服务成员有更大的问题时，他们需要区分线索时，视觉是不是一个可靠的输入。总之，这些发现表明EF对于解释感觉信息以识别慢性mTBI中的平衡挑战可能是重要的。
Among patients with traumatic brain injury (TBI), postural instability often persists chronically with negative consequences such as higher fall risk. One explanation may be reduced executive function (EF) required to effectively process, interpret and combine, sensory information. In other populations, a decline in higher cognitive functions are associated with a decline in walking and balance skills. Considering the link between EF decline and reduction in functional capacity, we investigated whether specific tests of executive function could predict balance function in a cohort of individuals with a history of chronic mild TBI (mTBI) and compared to individuals with a negative history of mTBI. Secondary analysis was performed on the local LIMBIC-CENC cohort (N = 338, 259 mTBI, mean 45 ± STD 10 age). Static balance was assessed with the sensory organization test (SOT). Hierarchical regression was used for each EF test outcome using the following blocks: (1) the number of TBIs sustained, age, and sex; (2) the separate Trail making test (TMT); (3) anti-saccade eye tracking items (error, latency, and accuracy); (4) Oddball distractor stimulus P300 and N200 at PZ and FZ response; and (5) Oddball target stimulus P300 and N200 at PZ and FZ response. The full model with all predictors accounted for between 15.2% and 21.5% of the variability in the balance measures. The number of TBI's) showed a negative association with the SOT2 score (p = 0.002). Additionally, longer times to complete TMT part B were shown to be related to a worse SOT1 score (p = 0.038). EEG distractors had the most influence on the SOT3 score (p = 0.019). Lastly, the SOT-composite and SOT5 scores were shown to be associated with longer inhibition latencies and errors (anti-saccade latency and error, p = 0.026 and p = 0.043 respectively). These findings show that integration and re-weighting of sensory input when vision is occluded or corrupted is most related to EF. This indicates that combat-exposed Veterans and Service Members have greater problems when they need to differentiate between cues when vision is not a reliable input. In sum, these findings suggest that EF could be important for interpreting sensory information to identify balance challenges in chronic mTBI.
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影响因子：
4.6
作者：
Bradford, J. Cortney;Lukos, Jamie R.;Ferris, Daniel P.
通讯作者：
Ferris, Daniel P.
影响因子：
7.2
作者：
Madley-Dowd, Paul;Hughes, Rachael;Heron, Jon
通讯作者：
Heron, Jon
影响因子：
1.9
作者：
Bazarian, JJ;Wong, T;Dombovy, M
通讯作者：
Dombovy, M
DOI：
10.1093/gerona/gls255
发表时间：
2013-07-01
影响因子：
5.1
作者：
Lord, Sue;Galna, Brook;Rochester, Lynn
通讯作者：
Rochester, Lynn
影响因子：
--
作者：
Kortte, Kathleen Bechtold;Horner, Michael David;Windham, Whitney K
通讯作者：
Windham, Whitney K