Isolation of ALP, a novel divergent murine CC chemokine with a unique carboxy terminal extension
Isolation of ALP, a novel divergent murine CC chemokine with a unique carboxy terminal extension
复制标题
DOI：
10.1006/bbrc.1999.0507
复制
发表时间：
1999-05-19
影响因子：
3.1
通讯作者：
Hou, YH
中科院分区：
文献类型：
--
作者：
Hromas, R;Broxmeyer, HE;Hou, YH
趋化因子是调节白细胞浸润到炎症组织中的相关蛋白质家族，在许多疾病过程中发挥重要作用。趋化因子根据其氨基末端半胱氨酸的序列分为CC和CXC两大类。本文报道了一种新型的小鼠CC趋化因子ALP的分离。这种新的趋化因子与其他CC趋化因子（与鼠Exodus-1/LARC/Mip-3 α具有37%的同一性）是远亲，但具有独特的羧基末端延伸。它优先在睾丸、心脏和肝脏中表达，这对于CC趋化因子是非典型的，（C）1999 Academic Press.
Chemokines are a family of related proteins that regulate leukocyte infiltration into inflamed tissue and play important roles in many disease processes. Chemokines are divided into two major groups, CC or CXC, based on their sequence around the amino terminal cysteines, We report here, the isolation of a novel murine CC chemokine termed ALP for its amino terminal peptide sequence. This novel chemokine is distantly related to other CC chemokines (37% identity with murine Exodus-1/LARC/Mip-3 alpha), but has a unique carboxy terminal extension. It is expressed preferentially in testis, heart, and liver, which is atypical for CC chemokines, (C) 1999 Academic Press.