AMINO-ACID SEQUENCE OF HUMAN APOLP-GLM-II (APON-II), AN APOLIPOPROTEIN ISOLATED FROM HIGH-DENSITY LIPOPROTEIN COMPLEX
AMINO-ACID SEQUENCE OF HUMAN APOLP-GLM-II (APON-II), AN APOLIPOPROTEIN ISOLATED FROM HIGH-DENSITY LIPOPROTEIN COMPLEX
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DOI：
10.1073/pnas.69.5.1304
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发表时间：
1972-01-01
影响因子：
11.1
通讯作者：
JOHN, KM
中科院分区：
文献类型：
--
作者：
BREWER, HB;RONAN, R;JOHN, KM
从人高密度脂蛋白家族中分离到一种载脂蛋白，其羧基末端残基为apoLp-Gln-II，并测定了其完整的氨基酸序列。载脂蛋白是该家族的两个主要载脂蛋白之一，由两个相同的多肽链组成，每个多肽链含有77个氨基酸。这两条多肽链在序列的第6位由一个二硫桥连接。完整载脂蛋白的最小分子量为17380。每条链的氨基末端残基为吡咯烷酮羧酸，羧基末端残基为谷氨酰胺。
An apolipoprotein, designated by its carboxyl-terminal residue as apoLp-Gln-II, has been isolated from the human high-density lipoprotein family, and its complete aminoacid sequence was determined. The apoprotein, one of the two major apoproteins of this family, is composed of two identical polypeptide chains, each containing 77 amino acids. The two polypeptide chains are connected by a single disulfide bridge at position 6 in the sequence. The minimum molecular weight of the intact apoprotein is 17,380. The amino-terminal residue of each chain is pyrrolidone carboxylic acid, and the carboxyl-terminal residue is glutamine.