Potential of nanofiber matrix as tissue-engineering scaffolds
Potential of nanofiber matrix as tissue-engineering scaffolds
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DOI：
10.1089/ten.2005.11.101
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发表时间：
2005-01-01
影响因子：
--
通讯作者：
Ramakrishna, S
中科院分区：
文献类型：
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作者：
Ma, ZW;Kotaki, M;Ramakrishna, S
组织工程支架在化学成分和物理结构方面应类似于天然细胞外基质（ECM）。聚合物纳米纤维基质与其纳米级非织造纤维 ECM 蛋白相似，因此是一种候选 ECM 模拟材料。静电纺丝等生产聚合物纳米纤维的技术促使研究人员探索纳米纤维基质作为组织工程支架的应用。本综述涵盖了未来组织工程支架开发中聚合物纳米纤维基质的制备和改性。重点还放在定向、核壳结构或表面功能化聚合物纳米纤维的开发和应用上。聚合物纳米纤维的潜在应用远远超出了组织工程的范围。由于其高表面积，功能化聚合物纳米纤维在未来将作为药物输送载体、生物传感器和分子过滤膜得到广泛的应用。
Tissue-engineering scaffolds should be analogous to native extracellular matrix (ECM) in terms of both chemical composition and physical structure. Polymeric nanofiber matrix is similar, with its nanoscaled nonwoven fibrous ECM proteins, and thus is a candidate ECM-mimetic material. Techniques such as electrospinning to produce polymeric nanofibers have stimulated researchers to explore the application of nanofiber matrix as a tissue-engineering scaffold. This review covers the preparation and modification of polymeric nanofiber matrix in the development of future tissue-engineering scaffolds. Major emphasis is also given to the development and applications of aligned, core shell-structured, or surface-functionalized polymer nanofibers. The potential application of polymer nanofibers extends far beyond tissue engineering. Owing to their high surface area, functionalized polymer nanofibers will find broad applications as drug delivery carriers, biosensors, and molecular filtration membranes in future.