Physiogenomic strategies and resources to associate genes with rat models of heart, lung and blood disorders.
Physiogenomic strategies and resources to associate genes with rat models of heart, lung and blood disorders.
复制标题
将基因与心脏、肺和血液疾病的大鼠模型联系起来的生理基因组策略和资源。
DOI：
10.1113/expphysiol.2006.036350
复制
发表时间：
2007
影响因子：
2.7
通讯作者：
Lee,NormanH
中科院分区：
文献类型：
--
作者：
Lee,NormanH
与许多人类疾病一样，心血管疾病是一种复杂的疾病，表现出多因素的传播方式。大鼠模型已经被开发出来，以帮助分析这种复杂的遗传和表型障碍。这篇简要综述的目的是描述目前已经实施的基因表达谱策略，以在动物模型中寻找疾病表型的候选致病基因。策略包括将基因表达信息与连锁分析相结合，对染色体替换和/或同源的大鼠品系进行表达谱分析，将基因表达与一组啮齿动物品系的生理数据相关联，以及将表达数量性状基因座与生理数量性状基因座联系起来。这些策略的一个主要目标是缩小和优先搜索生理感兴趣的因果基因。还讨论了利用两种最近公开可用的资源的方法，这两种资源是为了研究基因和环境在心血管生理学和病理生理学上的作用而创建的。
As is the case for many human disorders, cardiovascular disease is a complex ailment exhibiting a multifactorial mode of transmission. Rat models have been developed to aid in the analysis of this complex genetic and phenotypic disorder. The purpose of this brief review is to describe current gene expression profiling strategies that have been implemented to search for candidate causative genes of disease phenotypes in animal models. Strategies include integrating gene expression information with linkage analysis, expression profiling chromosome‐substituted and/or congenic rat strains, correlating gene expression with physiological data across a panel of rodent strains, and linking expression quantitative trait loci to physiological quantitative trait loci. A primary goal of these strategies is to narrow and prioritize the search for causal genes of physiological interest. Also discussed are ways to harness two recent publicly available resources that have been created to investigate the role of genes and environment on cardiovascular physiology and pathophysiology.