The immunological synapse balances T cell receptor signaling and degradation
The immunological synapse balances T cell receptor signaling and degradation
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DOI：
10.1126/science.1086507
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发表时间：
2003-11-14
期刊：
影响因子：
56.9
通讯作者：
Shaw, AS
中科院分区：
文献类型：
--
作者：
Lee, KH;Dinner, AR;Shaw, AS
免疫突触是 T 细胞和抗原呈递细胞表面之间的特殊细胞间连接。它的特征是中央抗原受体簇、整联蛋白家族粘附分子环以及数小时内的时间稳定性。这种特定组织在 T 细胞激活信号传导中的作用一直存在争议。我们使用体外和计算机实验来确定免疫突触作为一种自适应控制器，既可以增强 T 细胞受体触发，又可以减弱强信号。
The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals.