A recombinant carboxy-terminal domain of the protective antigen of Bacillus anthracis protects mice against anthrax infection
A recombinant carboxy-terminal domain of the protective antigen of Bacillus anthracis protects mice against anthrax infection
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DOI：
10.1128/iai.70.3.1653-1656.2002
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发表时间：
2002-03-01
影响因子：
3.1
通讯作者：
Williamson, ED
中科院分区：
文献类型：
--
作者：
Flick-Smith, HC;Walker, NJ;Williamson, ED
以谷胱甘肽S-转移酶融合蛋白的形式克隆和表达保护性抗原(PA)多肽的重叠区，对其免疫原性和保护作用进行了研究。结果表明，保护作用可以归因于单个结构域，这意味着包含PA主要保护性表位的是结构域4。
The immunogenicity and protective efficacy of overlapping regions of the protective antigen (PA) polypeptide, cloned and expressed as glutathione S-transferase fusion proteins, have been assessed. Results show that protection can be attributed to individual domains and imply that it is domain 4 which contains the dominant protective epitopes of PA.