Effects of hypoxia exposure on skeletal muscle in vivo
Effects of hypoxia exposure on skeletal muscle in vivo
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DOI：
10.7600/jspfsm.68.357
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发表时间：
2019-12
影响因子：
--
通讯作者：
H. Nagahisa;H. Miyata
中科院分区：
文献类型：
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作者：
H. Nagahisa;H. Miyata
骨骼肌的低氧状态不仅与低氧暴露有关，还与运动和疾病等因素有关。阐明体内对低氧的反应机制有助于制定更好的训练方法和治疗策略。然而，目前有关低氧暴露对骨骼肌影响的研究还没有显示出一致的结果。低氧暴露可导致血管生成或肌肉萎缩，表现为骨骼肌的形态变化。低氧暴露的应用包括间歇性低氧暴露和低氧训练，两者都可能以不同于正常低氧暴露的机制导致血管生成。在这篇综述中，我们介绍了一些关于低氧暴露对骨骼肌的影响的发现，并讨论了卫星细胞是否参与了低氧促进血管生成。
Hypoxic condition of skeletal muscle is caused not only by hypoxia exposure but also by exercise and disease etc. It is thought that clarifying a mechanism of response to hypoxia in vivo is useful for developing better training methods and treatment strategies. However, at present, research dealing with the effects of hypoxic exposure on skeletal muscle have not shown consistent results. Hypoxic exposure results in angiogenesis or muscle atrophy as mor-phological changes in skeletal muscle. Applications of hypoxic exposure include intermittent hypoxic exposure and hypoxic training, both of which may lead to angiogenesis in a mechanism different from normal hypoxic exposure. In this review, we present some findings on the effects of hypoxia exposure on skeletal muscle and discuss whether satellite cells are involved in promoting angiogenesis by hypoxia.