Idiopathic polyneuritis in SPF chickens.
Idiopathic polyneuritis in SPF chickens.
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SPF 鸡的特发性多发性神经炎。
DOI：
10.1080/03079458208436090
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
D. Cooper
中科院分区：
文献类型：
--
作者：
P. Biggs;R. Shilleto;A. Lawn;D. Cooper
在一群罗得岛红鸡中，在8年的时间内偶发性发生外周神经炎所致的麻痹，并将其命名为特发性神经炎（IP）。将鸡群圈养在隔离器中，并且不含许多常见病原体，包括所有已知的鸡嗜神经病毒。本文描述了神经病变的病理学，包括其超微结构，并与马立克氏病和鸡实验性变态反应性神经炎的病变进行了比较。脱髓鞘伴淋巴细胞和巨噬细胞浸润的神经纤维发生在所有三种疾病中，但在病变分布和细胞浸润强度方面存在差异。IP的病变与马立克氏病的B型病变最相似。试图分离细胞病变病毒并通过接种传播疾病，但未能证明其为感染性病原体。对正常神经的自身免疫反应被认为是几种替代方案中最可能的病因。IP的遗传性尚未确定，但在类似条件下饲养的轻型苏塞克斯鸡群中尚未检测到该疾病。
Paralysis due to peripheral neuritis occurred sporadically in a flock of Rhode Island Red chickens over a period of 8 years and is named idiopathic neuritis (IP). The flock was housed in isolators and free from many common pathogens including all known neurotropic viruses of chickens. The pathology of the nerve lesions, including their ultrastructure, is described and comparisons made with the lesions of Marek's disease and experimental allergic neuritis in chickens. Demyelination with invasion of nerve fibres with lymphocytes and macrophages occurs in all three diseases but there are differences in lesion distribution and intensity of cellular infiltration. The closest similarity is between the lesions of IP and the B-type lesions of Marek's disease. Attempts to isolate a cytopathic virus and to transmit the disease by inoculation failed to demonstrate an infectious causal agent. An autoimmune response to normal nerve is suggested as the most likely aetiology amongst several alternatives. The heritability of IP is not established, but the disease has not been detected in a light Sussex flock maintained under similar conditions.