Hemoglobin Switching in Sheep and Goats: Occurrence of Hemoglobins A and C in the Same Red Cell
Hemoglobin Switching in Sheep and Goats: Occurrence of Hemoglobins A and C in the Same Red Cell
复制标题
绵羊和山羊的血红蛋白转换：血红蛋白 A 和 C 在同一红细胞中的出现
DOI：
10.1126/science.185.4155.946
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发表时间：
1974
期刊：
影响因子：
56.9
通讯作者：
H. Bunn
中科院分区：
文献类型：
--
作者：
A. Nienhuis;H. Bunn
绵羊和山羊在贫血时从血红蛋白A（α2β2A）的合成转变为血红蛋白C（α2β2C）。我们已经证实贫血绵羊循环红细胞中存在不对称的杂合血红蛋白α2βAβC。因此，这些红细胞同时合成A和C血红蛋白。因此，开关似乎是介导的选择性基因表达，而不是通过克隆或细胞选择性机制。
Sheep and goats switch from the synthesis of hemoglobin A (α2β2A) to hemoglobin C (α2β2C) when made anemic. We have demonstrated the existence of the asymmetrical hybrid hemoglobin, α2βAβC, in the circulating red cells of anemic sheep. These erythroid cells, therefore, synthesized both A and C hemoglobin simultaneously. Thus, the switch appears to be mediated by selective gene expression rather than by a clonal or cellular selective mechanism.