Re-conceptualizing ASD Within a Dimensional Framework: Positive, Negative, and Cognitive Feature Clusters.
Re-conceptualizing ASD Within a Dimensional Framework: Positive, Negative, and Cognitive Feature Clusters.
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DOI：
10.1007/s10803-015-2539-x
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发表时间：
2016-01
影响因子：
3.9
通讯作者：
Wolf J
中科院分区：
文献类型：
--
作者：
Foss-Feig JH;McPartland JC;Anticevic A;Wolf J
美国国家心理健康研究所的研究领域标准的介绍和修订的诊断分类自闭症谱系障碍的最新诊断手册要求一种新的方式来概念化异质性ASD功能。我们提出了一个新的概念ASD，借用精神分裂症的文献聚类ASD功能沿着积极，消极和认知方面。我们认为，这种维度概念化可以提供更好的分类，诊断和治疗能力，应用和预测治疗反应，并探索潜在的神经和遗传改变，可能有助于特定的功能集群。我们建议提出的概念化可以推进该领域的方式，可能证明临床和生物学有用的理解和解决ASD内的异质性。
Introduction of the National Institute of Mental Health’s Research Domain Criteria and revision of diagnostic classification for Autism Spectrum Disorder in the latest diagnostic manual call for a new way of conceptualizing heterogeneous ASD features. We propose a novel conceptualization of ASD, borrowing from the schizophrenia literature in clustering ASD features along positive, negative, and cognitive dimensions. We argue that this dimensional conceptualization can offer improved ability to classify, diagnose, and treat, to apply and predict response to treatment, and to explore underlying neural and genetic alterations that may contribute to particular feature clusters. We suggest the proposed conceptualization can advance the field in a manner that may prove clinically and biologically useful for understanding and addressing heterogeneity within ASD.