Analytic review: Interleukin-6 in surgery, trauma, and critical care: part I: basic science.
Analytic review: Interleukin-6 in surgery, trauma, and critical care: part I: basic science.
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DOI：
10.1177/0885066610395678
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发表时间：
2011-01
影响因子：
3.1
通讯作者：
Kulaylat M
中科院分区：
文献类型：
--
作者：
Jawa RS;Anillo S;Huntoon K;Baumann H;Kulaylat M
多种细胞因子在对炎症刺激的反应中起作用。白细胞介素-6（IL-6）型细胞因子响应于组织损伤或炎性刺激而释放。它们在局部和全身发挥作用，产生各种生理反应，其中主要是急性期反应。IL-6型细胞因子表现出多效性和冗余作用。这是由于IL-6受体复合物的独特特征，其含有大多数IL-6型细胞因子共有的普遍存在的亚基以及精氨酸特异性亚基。
A variety of cytokines play a role in the response to an inflammatory stimulus. The interleukin-6 (IL-6)-type cytokines are released in response to tissue injury or an inflammatory stimulus. They act locally and systemically to generate a variety of physiologic responses, principal among them is the acute phase response. The IL-6 type cytokines demonstrate pleiotropy and redundancy of actions. This is made possible by the distinctive characteristics of the IL-6 receptor complex, which contains an ubiquitous subunit that is shared by most IL-6-type cytokines, as well as a cytokine-specific subunit.