Association of anemia and long-term survival in patients with pulmonary hypertension
Association of anemia and long-term survival in patients with pulmonary hypertension
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DOI：
10.1016/j.ijcard.2010.04.038
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发表时间：
2011-08-04
影响因子：
3.5
通讯作者：
Bashore, Thomas M.
中科院分区：
文献类型：
--
作者：
Krasuski, Richard A.;Hart, Stephen A.;Bashore, Thomas M.
背景：贫血是左心室功能不全所致心力衰竭患者临床结局恶化的标志。肺动脉高压常导致右心室功能障碍。因此，我们试图研究的血红蛋白水平和长期的全因死亡率在一个队列的患者肺动脉高压。方法：基线人口统计学信息，临床特征和空腹血液工作中获得的一个队列的145例肺动脉高压患者提到肺血管扩张剂测试。数据进行回顾性分析与Cox比例hazardsanalysis.Results：基线特征的队列包括年龄（平均值+/- SD）55.8 +/- 14.6岁，75%的女性，50%的特发性肺动脉高压，平均肺动脉压46.1 +/- 14.2毫米汞柱和动脉氧饱和度91 +/-6%。最常用的肺动脉高压特异性治疗药物按频率降序排列为依前列醇（27%）、西地那非（21%）、波生坦（17%）和曲前列尼尔（6%）。中位随访时间为2.1年，有39例死亡（26.9%）。死亡患者的血红蛋白水平显著低于存活患者（12.2 +/- 2.3 vs. 13.7 +/- 2.0，p
Background: Anemia is a marker of worsened clinical outcome in patients with heart failure from left ventricular dysfunction. Pulmonary hypertension often results in right ventricular dysfunction. Accordingly we sought to examine the association of hemoglobin levels and long-term all-cause mortality in a cohort of patients with pulmonary hypertension.Methods: Baseline demographic information, clinical characteristics and fasting blood work were obtained in a cohort of 145 patients with pulmonary hypertension referred for pulmonary vasodilator testing. Data was retrospectively analyzed with Cox-proportional hazards analysis.Results: Baseline characteristics of the cohort included age (mean +/- SD) 55.8 +/- 14.6 years, 75% women, 50% with idiopathic pulmonary hypertension, mean pulmonary artery pressure 46.1 +/- 14.2 mm Hg and arterial O-2 saturation 91 +/- 6%. The most commonly utilized pulmonary hypertension specific therapeutic agents in descending order of frequency were epoprostenol (27%), sildenafil (21%), bosentan (17%), and treprostinil (6%). Over a median follow-up of 2.1 years, there were 39 deaths (26.9%). Patients who died had significantly lower hemoglobin levels than those survived (12.2 +/- 2.3 vs. 13.7 +/- 2.0, p