Benzolignanoid and polyphenols from Origanum vulgare
Benzolignanoid and polyphenols from Origanum vulgare
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DOI：
10.1002/jccs.200300153
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发表时间：
2003-10-01
影响因子：
1.8
通讯作者：
Wang, WY
中科院分区：
文献类型：
--
作者：
Lin, YL;Wang, CN;Wang, WY
一种新的二氢苯二氧杂环衍生物，原alignanol(10)，连同9种多酚类化合物，丹酚酸A(1)，丹酚酸C(2)，石精酸(3)，芹菜素7- o - β - d -（6”-甲基）葡萄糖醛酸(5)，木犀草素(6)，木犀草素7- o - β - d -葡萄糖醛酸(7)，木犀草素7- o - β - d -葡萄糖醛酸(7)，木犀草素7- o - β - d -葡萄糖醛酸(7)，木犀草素7- o - β - d -木犀草素(8)，木犀草素7- o - β - d -木犀草素(8)，木犀草素7- o - β - d -木犀草素(9)，从芫花地上部乙醇水提液中首次分离得到。利用光谱学方法确定了新化合物10的结构。化合物5可能是隔离过程中形成的产物。化合物1、2和3具有较强的DPPH自由基清除活性，EC50分别为7.2 +/- 0.4、9.6 +/- 0.9和9.5 +/- 0.7 muM，并能保护大鼠肝细胞免受100 muM的ccl4损伤。
A new dihydrobenzodioxane derivative, origalignanol (10), together with nine polyphenolic compounds, salvianolic acid A (1), salvianolic acid C (2), lithospermic acid (3), apigenin 7-O-beta-D-glucuronide (4), apigenin 7-O-beta-D-(6"-methyl)glucuronide (5), luteolin, (6), luteolin 7-O-beta-D-glucopyranoside (7), luteolin 7-O-beta-D-glucuronide (8), and luteolin 7-O-beta-D-xylopyranoside (9), were isolated from the aqueous ethanolic extract of the aerial parts of Origanum vulgare for the first time. The structure of new compound 10 was determined on the basis of spectroscopic methods. Compound 5 is probably an artifact formed during the isolation. Compounds 1, 2 and 3 showed strong DPPH radical scavenging activity with an EC50 of 7.2 +/- 0.4, 9.6 +/- 0.9, and 9.5 +/- 0.7 muM, respectively, and protected rat hepatocytes from CCl4-damage at 100 muM.