Simvastatin promotes osteogenesis around titanium implants - A histological and histometrical study in rats
Simvastatin promotes osteogenesis around titanium implants - A histological and histometrical study in rats
复制标题
DOI：
10.1046/j.1600-0501.2003.01015.x
复制
发表时间：
2004-06-01
影响因子：
4.3
通讯作者：
Koyano, K
中科院分区：
文献类型：
--
作者：
Ayukawa, Y;Okamura, A;Koyano, K
目的：羟甲基戊二酰辅酶A还原酶抑制剂，即所谓的他汀类药物，已被广泛用于高血压患者，最近有报道说，它促进骨形成。在本研究中，我们研究了辛伐他汀对周围的钛implants.Materials和方法促进成骨的效果：10个30周龄的大鼠接受纯钛种植体在两个tiphilis，然后分为实验组和对照组。实验组每日给予辛伐他汀治疗。30天后处死所有动物，制备标本。结果：对照组种植体周围可见新生骨形成，种植体周围骨密度（BD）、种植体与骨的接触率（BCR）、种植体周围骨密度（BD）、种植体周围骨密度（BMD）。观察到其与植入物表面直接接触，但偶尔插入未矿化结缔组织。在髓管内，观察到少量骨小梁。实验组髓腔内骨小梁较粗，呈网状结构。在组织计量学观察中，实验组的BCR和BD均显著大于对照组。结论：辛伐他汀的给药增加了BCR和BD的值。这种药物可能有潜力改善骨整合的性质。
Objectives: Hydroxymethylglutaryl-coenzyme A reductase inhibitors, the so-called statins, have been widely used for hyperlipidemic patients, and it was recently reported that it promoted bone formation. In the present study, we examined the effect of simvastatin on the promotion of osteogenesis around titanium implants.Materials and methods: Ten 30-week-old rats received pure titanium implants in both tibiae, and were then divided into experimental and control groups. The experimental group was administered simvastatin daily. Thirty days later, all animals were killed and then specimens were prepared. The bone contact ratio (BCR) to the implant and bone density (BD) around the implant, as well as histological findings, were obtained.Results: In the control group, newly formed bone could be seen around the implants. It was seen to be in direct contact with the implant surface, but otherwise unmineralized connective tissue was occasionally interposed. In the medullary canal, a scanty amount of bone trabeculae was observed. In the experimental group, in contrast, thicker bone trabeculae were abundantly seen in the medullary canal and showed a mesh-like structure. In the histometrical observations, both BCR and BD of the experimental group were significantly greater than those of the control group.Conclusion: The administration of simvastatin increases the value of both BCR and BD. This drug may have the potential to improve the nature of osseointegration.