Immunogenicity and safety of inactivated chromatographically purified Vero cell-derived Japanese encephalitis vaccine in Thai children
Immunogenicity and safety of inactivated chromatographically purified Vero cell-derived Japanese encephalitis vaccine in Thai children
复制标题
DOI：
10.1080/21645515.2017.1414763
复制
发表时间：
2018-01-01
影响因子：
4.8
通讯作者：
Zhumu, Bai
中科院分区：
文献类型：
--
作者：
Chanthavanich, Pornthep;Limkittikul, Kriengsak;Zhumu, Bai
小鼠脑源性乙型脑炎灭活疫苗安全性令人担忧，减毒活疫苗不适合免疫缺陷。本研究旨在评价层析纯化的灭活vero细胞来源的乙脑疫苗（cvi -乙脑，北京P-3株）在儿童中的免疫原性和安全性。152名健康的泰国儿童，平均（SD）年龄为14.4（3.8）个月，分别在第0天、第7-28天和第1年接受了3剂cvi -乙脑疫苗。测定同源乙脑中和抗体滴度（NT）。所有受试者在第二次接种后28天均有血清保护[几何平均滴度（GMT） 150]。初次接种后1年和加强后1个月的血清保护率分别为89.3% （GMT 49）和100% （GMT 621）。在接种疫苗后28天内发现了局部和全身反应——发烧（17.6%）、呕吐（8%）和食欲不振（5.3%）。所有这些症状都是自限性的。结论：cvi -乙脑是安全的，具有免疫原性，并提供高NT。
Inactivated mouse-brain-derived Japanese encephalitis vaccine has a worrisome safety profile and the live attenuated vaccine is unsuitable in immunodeficiency. This study aimed to evaluate the immunogenicity and safety of an inactivated chromatographically purified Vero-cell-derived JE vaccine (CVI-JE, Beijing P-3 strain) in children.152 healthy Thai children, with an average (SD) age of 14.4 (3.8) months, received 3 doses of CVI-JE on days 0, 7-28, and one year. Homologous JE neutralizing antibody titers (NT) were measured. All subjects had seroprotection [geometric mean titer (GMT) 150] 28 days' post 2nd vaccination. The seroprotection rates at 1 year after primary series and and 1 month after the booster were 89.3% (GMT 49) and 100% (GMT 621), respectively. Local and systemic reactions-fever (17.6%), vomiting (8%), and poor appetite (5.3%)-were noted within 28 days' post-vaccination. All these symptoms were self-limited. Conclusions: CVI-JE is safe, immunogenic, and provided high NT.