Gene therapy in the neuroendocrine system.
Gene therapy in the neuroendocrine system.
复制标题
神经内分泌系统的基因治疗。
DOI：
10.1159/000094316
复制
发表时间：
2006
影响因子：
--
通讯作者：
Goya,RG
中科院分区：
文献类型：
--
作者：
Hereñú,CB;Morel,GR;Bellini,MJ;Reggiani,PC;Sosa,YE;Brown,OA;Goya,RG
在神经内分泌疾病的动物模型中实施实验性基因治疗是一个越来越受关注的领域。在下丘脑中，恢复性基因治疗已成功地在Brattleboro大鼠（一种精氨酸加压素（AVP）突变体，其患有尿崩症）和Koletsky（fak/fak）和Zucker（fa/fa）大鼠（其具有使其肥胖、过度吞噬和高胰岛素血症的瘦素受体突变）中实施。在上述模型中，将分别表达AVP、瘦素受体B和阿黑皮素原的病毒载体立体定位注射到相关的下丘脑区域。在大鼠中，衰老导致下丘脑结节漏斗多巴胺能（TIDA）神经元的进行性变性和丢失，TIDA神经元参与催乳素分泌和催乳细胞增殖的紧张性抑制控制。立体定向注射表达胰岛素样生长因子I的腺病毒载体纠正了他们的慢性高泌乳素血症，恢复了TIDA神经元数量。自发性垂体中叶肿瘤视网膜母细胞瘤（Rb）基因突变小鼠通过注射腺病毒载体表达的人Rb cDNA和大鼠实验性泌乳素瘤进行了纠正垂体内注射腺病毒载体表达的HSV 1-胸苷激酶自杀基因。这些结果表明，在神经内分泌模型中进一步实施基因治疗策略可能是非常有益的。
The implementation of experimental gene therapy in animal models of neuroendocrine diseases is an area of growing interest. In the hypothalamus, restorative gene therapy has been successfully implemented in Brattleboro rats, an arginine vasopressin (AVP) mutant which suffers from diabetes insipidus, and in Koletsky (fak/fak) and in Zucker (fa/fa) rats which have leptin receptor mutations that render them obese, hyperphagic and hyperinsulinemic. In the above models, viral vectors expressing AVP, leptin receptor b and proopiomelanocortin, respectively, were stereotaxically injected in the relevant hypothalamic regions. In rats, aging brings about a progressive degeneration and loss of hypothalamic tuberoinfundibular dopaminergic (TIDA) neurons, which are involved in the tonic inhibitory control of prolactin secretion and lactotropic cell proliferation. Stereotaxic injection of an adenoviral vector expressing insulin-like growth factor I corrected their chronic hyperprolactinemia and restored TIDA neuron numbers. Spontaneous intermediate lobe pituitary tumors in a retinoblastoma (Rb) gene mutant mouse were corrected by injection of an adenoviral vector expressing the human Rb cDNA and experimental prolactinomas in rats were partially reduced by intrapituitary injection of an adenoviral vector expressing the HSV1-thymidine kinase suicide gene. These results suggest that further implementation of gene therapy strategies in neuroendocrine models may be highly rewarding.
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影响因子：
3
作者：
PORTER, JC;NANSEL, DD;TILDERS, FJH
通讯作者：
TILDERS, FJH
影响因子：
2.5
作者：
Sánchez, HL;Silva, LB;Zuccolilli, GO
通讯作者：
Zuccolilli, GO
腺病毒介导的单纯疱疹病毒 1 型胸苷激酶基因治疗可抑制雌激素诱导的垂体催乳素瘤。
DOI：
10.1210/jcem.85.3.6482
发表时间：
2000
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
S. Windeatt;T. Southgate;Ricardo A. Dewey;Federico Bolognani;M. Perone;A. Larregina;T. Maleniak;I. Morris;R. G. Goya;D. Klatzmann;P. Lowenstein;M. G. Castro
通讯作者：
M. G. Castro
中枢神经系统的长期基因治疗：通过使用表达精氨酸加压素的腺病毒逆转布拉特尔伯勒大鼠的下丘脑尿崩症
影响因子：
82.9
作者：
B. Geddes;T. Harding;S. Lightman;J. Uney
通讯作者：
J. Uney
影响因子：
4.8
作者：
Morton, GJ;Niswender, KD;Schwartz, MW
通讯作者：
Schwartz, MW