MAP kinase signalling cascade in Arabidopsis innate immunity
MAP kinase signalling cascade in Arabidopsis innate immunity
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DOI：
10.1038/415977a
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发表时间：
2002-02-28
期刊：
影响因子：
64.8
通讯作者：
Sheen, J
中科院分区：
文献类型：
--
作者：
Asai, T;Tena, G;Sheen, J
植物、昆虫和哺乳动物的先天免疫应答对病原相关分子模式（PAMPs）的识别具有显著的保守性。我们开发了一个拟南芥叶细胞系统的基础上诱导早期防御基因转录的鞭毛蛋白，高度保守的组成部分，细菌鞭毛的功能作为一个PAMP在植物和哺乳动物。在这里，我们确定了一个完整的植物MAP激酶级联（MEKK 1，MKK 4/MKK 5和MPK 3/MPK 6）和WRKY 22/WRKY 29转录因子的鞭毛蛋白受体FLS 2，富含亮氨酸重复序列（LRR）受体激酶的下游功能。这种MAPK级联的激活赋予对细菌和真菌病原体的抗性，这表明由不同病原体引发的信号传导事件汇聚成保守的MAPK级联。
There is remarkable conservation in the recognition of pathogen-associated molecular patterns (PAMPs) by innate immune responses of plants, insects and mammals. We developed an Arabidopsis thaliana leaf cell system based on the induction of early-defence gene transcription by flagellin, a highly conserved component of bacterial flagella that functions as a PAMP in plants and mammals. Here we identify a complete plant MAP kinase cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) and WRKY22/WRKY29 transcription factors that function downstream of the flagellin receptor FLS2, a leucine-rich-repeat (LRR) receptor kinase. Activation of this MAPK cascade confers resistance to both bacterial and fungal pathogens, suggesting that signalling events initiated by diverse pathogens converge into a conserved MAPK cascade.