Plasma homocysteine concentrations and depression: A twin study.
Plasma homocysteine concentrations and depression: A twin study.
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DOI：
10.1016/j.jadr.2021.100087
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发表时间：
2021-04-01
影响因子：
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通讯作者：
Vaccarino, Viola
中科院分区：
文献类型：
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作者：
Bremner, J Douglas;Goldberg, Jack;Vaccarino, Viola
背景技术背景：同型半胱氨酸是一种在代谢过程中形成的氨基酸，在能量代谢和神经递质合成中起重要作用的必需氨基酸蛋氨酸。高水平的同型半胱氨酸与抑郁症和心血管疾病有关，但抑郁症的研究并不总是一致的，可能与研究方法的差异有关。在临床研究中对双胞胎的研究在控制混杂因素方面是有用的。本研究的目的是评估抑郁症和血浆同型半胱氨酸之间的关系，在一项研究的twins.METHODS：同型半胱氨酸浓度进行了评估，在双胞胎（N = 202）从越南时代双胞胎登记处，包括双胞胎对不一致的诊断为重度抑郁症（MDD）和双胞胎对没有MDD。采用Beck抑郁量表（BDI）对抑郁症状水平进行连续测量。结果：同型半胱氨酸浓度平均为7.9 mumol/L（2.1 mumol/L SD，范围为2.0-17.1 mumol/L）。在MDD不一致的双胞胎和BDI评分不同的双胞胎中，同型半胱氨酸浓度没有双胞胎之间的差异。通过平均BDI评分和同型半胱氨酸浓度测量的抑郁症状之间存在显著的配对水平关系，例如双胞胎对的平均BDI评分越高，该对的平均同型半胱氨酸越高（p <0.001）。每增加10分的BDI评分与0.8 μ mol/L的增加同型半胱氨酸浓度在对level.CONCLUSIONS：这些研究结果是不一致的因果关系的作用升高同型半胱氨酸在抑郁症的发展，而是指向家族混杂或其他因素，是由双胞胎兄弟共享，并有助于抑郁症和同型半胱氨酸水平。
BACKGROUND: Homocysteine is an amino acid formed during metabolism of the essential amino acid methionine that plays an important role in energy metabolism and neurotransmitter synthesis. High levels of homocysteine have been linked to both depression and cardiovascular disease, however studies of depression have not always been consistent, possibly related to differences in methodology among studies. The study of twins in clinical research can be useful in controlling for confounding factors. The purpose of this study was to assess the relationship between depression and plasma homocysteine in a study of twins.METHODS: Homocysteine concentration was assessed in twins (N = 202) from the Vietnam Era Twin Registry, including twin pairs discordant for the diagnosis of Major Depressive Disorder (MDD) and twin pairs without MDD. Self reported depressive symptom levels were also measured as a continous variable using the Beck Depression Inventory (BDI).RESULTS: The average homocysteine concentration was 7.9 mumol/L (2.1 mumol/L SD, range of 2.0-17.1 mumol/L). There were no within twin pair differences in homocysteine concentration within twin pairs discordant for MDD and within twin pairs that differed for BDI score. There was a significant pair-level relationship between depressive symptoms as measured by mean BDI score and homocysteine concentration, such that the higher the mean BDI score of the twin pair, the higher the mean homocystein of the pair (p < .001). Every 10 point increase in BDI score was associated with an 0.8 mumol/L increase in homocysteine concentration at the pair level.CONCLUSIONS: These findings are not consistent with a causal role for elevated homocysteine in the development of depression, but rather point to familial confounding or other factors that are shared by twin brothers and that contribute to both depression and homocysteine levels.