A light-activatable photosensitizer for photodynamic therapy based on a diarylethene derivative.
A light-activatable photosensitizer for photodynamic therapy based on a diarylethene derivative.
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DOI：
10.1039/d1cc02102h
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发表时间：
2021-07
影响因子：
4.9
通讯作者：
J. Zhang;Ran Zhang;Kaiqiang Liu;Yong Li;Xu Wang;Xilei Xie;Xiaoyun Jiao;Bo Tang
中科院分区：
文献类型：
--
作者：
J. Zhang;Ran Zhang;Kaiqiang Liu;Yong Li;Xu Wang;Xilei Xie;Xiaoyun Jiao;Bo Tang
本文中，开发了基于二芳基乙烯衍生物的光活化光敏剂DAE-TPE用于光动力疗法。在UV暴露后，DAE-TPE NP的“开放”形式（OF）转化为“封闭”形式（CF），并且光敏化被激活。DAE-TPE NP的CF对HeLa细胞表现出足够的光动力治疗效果。
Herein, a light-activatable photosensitizer based on a diarylethene derivative, DAE-TPE, was developed for photodynamic therapy. Upon UV exposure, the "opened" form (OF) of DAE-TPE NPs was converted to the "closed" form (CF), and photosensitization was activated. The CF of DAE-TPE NPs exhibited sufficient photodynamic therapy effects upon HeLa cells.