Identification of ZDHHC1 as a Pyroptosis Inducer and Potential Target in the Establishment of Pyroptosis-Related Signature in Localized Prostate Cancer.
Identification of ZDHHC1 as a Pyroptosis Inducer and Potential Target in the Establishment of Pyroptosis-Related Signature in Localized Prostate Cancer.
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鉴定 ZDHHC1 作为焦亡诱导剂和在局限性前列腺癌中建立焦亡相关特征的潜在靶标
DOI：
10.1155/2022/5925817
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发表时间：
2022
影响因子：
--
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细胞焦亡或细胞炎性坏死是一种程序性细胞死亡。越来越多的证据表明焦亡在肿瘤细胞的侵袭、转移和增殖中发挥着至关重要的作用，从而影响肿瘤的预后和治疗效果。前列腺癌（PCa）是男性常见的恶性肿瘤，与炎症有关。焦亡对肿瘤发生和进展以及 PCa 介导的病理生理学影响是已知的，但其对 PCa 潜在预后的影响值得深入研究。在此，我们建立了六个焦亡相关基因的风险模型，并验证了它们对预后和治疗效果的预测能力。较高的风险评分表明生化复发（BCR）的可能性较高、免疫浸润较高以及临床病理特征恶化。为了对 PCa 患者的 BCR 进行科学、可靠的预测，在癌症基因组图谱 (TCGA) 数据集进行评估后，当前研究的结果在基因表达综合 (GEO) 队列中得到了验证。此外，在评估模型中的六个基因后，发现ZDHHC1是一个重要组成部分。通过体内和体外实验进一步评估其抗肿瘤作用，并进一步评估和验证其对细胞焦亡的促进作用。上述结果为进一步研究细胞焦亡及其治疗PCa的临床应用提供了新的视角。
Pyroptosis or cellular inflammatory necrosis is a programmed cell death kind. Accumulating evidence shows that pyroptosis plays a crucial role in the invasion, metastasis, and proliferation of tumor cells, thus affecting the prognosis of tumors and therapeutic effects. Prostate cancer (PCa), a common malignancy among men, is associated with inflammation. Pathophysiological effects of pyroptosis on tumor development and progression, as well as the mediation of PCa, are known, but its effects on the potential prognosis for PCa warrant in-depth investigation. Herein, we built a risk model of six pyroptosis-related genes and verified their predictive abilities for prognostic and therapeutic effects. Higher risk scores indicated a higher probability of biochemical recurrence (BCR), higher immune infiltration, and worsened clinicopathological features. To derive scientific and reliable predictions for BCR in patients having PCa, the findings of the current study were verified in the Gene Expression Omnibus (GEO) cohort following evaluation in The Cancer Genome Atlas (TCGA) dataset. Additionally, after evaluating the six genes in the model, ZDHHC1 was found to be an important component. Its antitumor role was further assessed through in vivo and in vitro experiments, and its promoting effect on pyroptosis was further evaluated and verified. The above results provided a new perspective for further studies on pyroptosis and its clinical utility for PCa.
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影响因子：
10.5
作者：
Santanam U;Banach-Petrosky W;Abate-Shen C;Shen MM;White E;DiPaola RS
通讯作者：
DiPaola RS
DNA 甲基化下调 ZDHHC1 通过改变细胞代谢和诱导氧化/内质网应激介导的细胞凋亡和焦亡来抑制肿瘤生长
影响因子：
12.4
作者：
Le, Xin;Mu, Junhao;Xiang, Tingxiu
通讯作者：
Xiang, Tingxiu
影响因子：
3.1
作者：
Hilbi, H;Chen, YJ;Zychlinsky, A
通讯作者：
Zychlinsky, A
影响因子：
64.5
作者：
Rooney MS;Shukla SA;Wu CJ;Getz G;Hacohen N
通讯作者：
Hacohen N
DOI：
10.1126/science.aas8995
发表时间：
2020-09-18
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Magupalli VG;Negro R;Tian Y;Hauenstein AV;Di Caprio G;Skillern W;Deng Q;Orning P;Alam HB;Maliga Z;Sharif H;Hu JJ;Evavold CL;Kagan JC;Schmidt FI;Fitzgerald KA;Kirchhausen T;Li Y;Wu H
通讯作者：
Wu H