Neurological Deficits After Long-term Pyrethroid Exposure.
Neurological Deficits After Long-term Pyrethroid Exposure.
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DOI：
10.1177/1178630217700628
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发表时间：
2017
影响因子：
2.7
通讯作者：
Schlünssen V
中科院分区：
文献类型：
--
作者：
Hansen MRH;Jørs E;Lander F;Condarco G;Debes F;Bustillos NT;Schlünssen V
拟除虫菊酯农药被认为是帕金森病和其他神经退行性疾病的原因之一。为了调查这一点，对120名玻利维亚公共卫生媒介计划喷雾者进行了横断面研究，这些人主要接触拟除虫菊酯。农药暴露和中枢神经系统(CNS)症状通过结构化访谈确定，而神经运动和神经认知能力则使用计算机化行为评估和研究系统和CATsys系统进行评估。暴露于较高水平的个体报告的中枢神经系统症状明显更多(调整后的优势比每五分位数的累积暴露 = 2.01[1.22-3.31])。在拟除虫菊酯暴露和神经运动表现之间没有发现联系。在结构方程模型中，较高的喷洒强度与明显较差的神经认知表现相关(调整后的每五分位数β = −0.405[−0.660至−0.150])，且只接触拟除虫菊酯的工人的表现比接触其他农药的工人差(调整后的β = −1.344[−2.224至−0.464])。长期接触拟除虫菊酯可能会导致神经认知能力下降，建议进行接触控制。
Pyrethroid pesticides have been suggested to be a cause of Parkinson disease and other neurodegenerative diseases. To investigate this, a cross-sectional study was conducted among 120 Bolivian public health vector program spray men, primarily exposed to pyrethroids. Pesticide exposure and central nervous system (CNS) symptoms were determined by a structured interview, whereas neuromotor and neurocognitive performance was assessed using the computerized Behavioral Assessment and Research System and CATSYS system. Individuals exposed to higher levels reported significantly more CNS symptoms (adjusted odds ratio per quintile of cumulative exposure = 2.01 [1.22-3.31]). There was no association seen between pyrethroid exposure and neuromotor performance. Higher spraying intensity was associated with significantly worse neurocognitive performance in structural equation models (adjusted β per quintile = −0.405 [−0.660 to −0.150]), and workers only exposed to pyrethroids performed worse than workers also exposed to other pesticides (adjusted β = −1.344 [−2.224 to −0.464]). Chronic pyrethroid exposure may cause deterioration in neurocognitive performance, and exposure control is recommended.