Evolutionary dynamics of cancer prevention.

Evolutionary dynamics of cancer prevention.
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DOI:
10.1038/nrc2892
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发表时间:
2010-08
期刊:
Nature reviews. Cancer
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多细胞生物在繁殖之前必须进化出抑制癌症形成的机制,我们认为正常上皮的组织结构就是这样一种策略。了解进化的宿主癌症抑制机制对于确定癌变的第一步和制定合理的癌症预防策略至关重要。
Multicellular organisms must evolve mechanisms to suppress cancer formation prior to reproduction, and we propose that the organizational structure of normal epithelium is one such strategy. Understanding evolved host cancer suppression mechanisms is essential to defining the first steps of carcinogenesis and developing rational cancer prevention strategies.