Structural changes in membranes produced by the binding of small amphipathic molecules.
Structural changes in membranes produced by the binding of small amphipathic molecules.
复制标题
小两亲分子的结合产生膜的结构变化。
DOI：
10.1021/bi00297a010
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发表时间：
1984
期刊：
影响因子：
2.9
通讯作者：
Singer,SJ
中科院分区：
文献类型：
--
作者：
Maher,P;Singer,SJ
Pamela Maher和SJ Singer*摘要：在与膜的相互作用中，两亲小分子表现出类似洗涤剂的特性。在足够高的浓度下（如果它们形成胶束，则高于临界胶束浓度），它们基本上会溶解膜。在较低的浓度下，在最大的抗溶血和溶血之间，我们在这里表明，两路通路显着扰乱膜结构。六种小分子双通道中的每一种都通过吸湿脱吸过滤来诱导提取少量但重要的膜成分，部分以形式存在
Pamela Maher and SJ Singer* abstract: In their interactions with membranes, amphipathic small molecules exhibit detergent-like properties. At suffi-ciently high concentrations (above their critical micelle con-centrations, if they form micelles), they substantially dissolve membranes. At lower concentrations, between maximally antihemolytic and lytic, we show here that the amphipaths significantly perturb membrane structure. Each of six small-molecule amphipaths was shown by hygroscopic de-sorption filtration to induce the extraction of small but sig-nificant amounts of membrane components, partly in the form