Effects of a transferring antibody against Neospora caninum infection in a murine model.
Effects of a transferring antibody against Neospora caninum infection in a murine model.
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DOI：
10.1016/j.vetpar.2008.10.095
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发表时间：
2009-03
影响因子：
2.6
通讯作者：
Y. Nishikawa;Houshuang Zhang;Penglong Huang;Guohong Zhang;X. Xuan
中科院分区：
文献类型：
--
作者：
Y. Nishikawa;Houshuang Zhang;Penglong Huang;Guohong Zhang;X. Xuan
我们研究了转移抗体的作用，抗新孢子虫感染的小鼠模型的基础上，使用重组牛痘病毒携带NcSRS2基因。与对照组相比，在接种疫苗的母鼠的存活后代中检测到更高水平的抗NcSRS2抗体，而在未接种疫苗的母鼠的存活后代中检测到转移性抗NcSAG1抗体。交配后，用转抗N.在妊娠中期用寄生虫攻击犬。在妊娠期间，转移抗体在寄生虫感染后消失。母鼠体内寄生虫负荷和子代存活率无显著差异。在这里，我们证明了N.犬特异性转移抗体不能控制小鼠中的寄生虫感染。
We investigated the roles of a transferring antibody against Neospora caninum infection based on a murine model using recombinant vaccinia virus carrying NcSRS2 gene. Higher levels of anti-NcSRS2 antibody were detected in surviving offspring from vaccinated dams than controls while the transferring anti-NcSAG1 antibody was detected in the surviving offspring from unvaccinated dams. After mating, the female mice with transferring antibody against N. caninum were challenged with the parasites in mid-gestation. The transferring antibodies disappeared during pregnancy upon parasite infection. There was no significant difference on the parasite burden in dams and the survival rates of their offspring. Here, we have shown that N. caninum-specific transferring antibody does not control parasite infection in mice.