Anti-oncogenic activity of Chibby in the development of human nasopharyngeal carcinoma
Anti-oncogenic activity of Chibby in the development of human nasopharyngeal carcinoma
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Chibby 在人鼻咽癌发展中的抗癌活性
DOI：
10.3892/ol.2018.8009
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发表时间：
2018-04-01
期刊：
影响因子：
2.9
通讯作者：
Li, Yi-Meng
中科院分区：
文献类型：
--
作者：
Cai, Cheng-Fu;Liu, Li-Man;Li, Yi-Meng
Wnt/β-连环蛋白通路在癌症发展中起重要作用。Chibby（Cby）作为β-catenin的直接拮抗剂，其在鼻咽癌中的表达及功能尚未完全阐明。本研究发现，鼻咽癌组织中Cby的mRNA和蛋白表达均明显低于癌旁正常组织。Cby蛋白低表达与肿瘤的临床分期及肿瘤大小有关。Cby过表达可抑制人鼻咽癌SUNE 1细胞的增殖并诱导细胞周期阻滞。此外，Cby过表达还显著增强SUNE 1细胞对凋亡的易感性。这些结果提示Cby基因可能作为一个抑癌基因参与了鼻咽癌的发生发展，并可能成为鼻咽癌治疗的一个潜在靶点。
The Wnt/beta-catenin pathway serves important roles in cancer development. The expression and function of Chibby (Cby), as a direct antagonist of beta-catenin, in nasopharyngeal carcinoma (NPC) has not been fully investigated. The present study revealed that the mRNA and protein expression of Cby was significantly lower in NPC tissue than in the adjacent normal tissue. Low expression of Cby was significantly associated with the tumor and the clinical staging. Furthermore, Cby overexpression inhibited the proliferation of human NPC SUNE1 cells and induced cell cycle arrest. In addition, Cby overexpression also significantly enhanced the susceptibility of SUNE1 cells to apoptosis. These results indicated that Cby might serve as an anti-oncogenic gene in the development of NPC and could represent a potential therapeutic target for the human NPC therapy.