Different risk factor profiles for mucinous and nonmucinous ovarian cancer:: Results from the Danish MALOVA study
Different risk factor profiles for mucinous and nonmucinous ovarian cancer:: Results from the Danish MALOVA study
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DOI：
10.1158/1055-9965.epi-07-0089
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发表时间：
2007-06-01
影响因子：
3.8
通讯作者：
Kjaer, Susanne K.
中科院分区：
文献类型：
--
作者：
Soegaard, Marie;Jensen, Allan;Kjaer, Susanne K.
目的：本研究的目的是检查上皮性卵巢癌的总体危险因素，并根据组织学subtypes.Materials和方法：卵巢癌病例和对照组招募1995年至1999年，并进行个人访谈。共纳入554例病例和1，564例随机选择的对照。结果：卵巢癌的总体危险性随着妊娠次数的增加而降低[比值比（OR），0.40; 95%可信区间（0），0.30-0.55]，随着妊娠次数的增加而降低两次和三次妊娠与一次妊娠相比，OR分别为0.63; 95%CI为0.45-0.87和0.51; 95%CI为0.37-0.69。排卵年数的增加是一个非常强的风险因素，每排卵一年，风险增加7%至8%。口服避孕药的使用（OR，0.67，95%CI，0.53-0.85）和较长的使用时间与卵巢癌的风险降低相关。曾使用激素替代治疗增加了总体风险（OR，1.30; 95%CI，1.05-1.61）。对于所有这些变量，该效应存在于浆液性肿瘤、类浆液性肿瘤和其他组织学类型的肿瘤，但不存在于粘液性肿瘤。相比之下，目前吸烟是一个危险因素，只有粘液性肿瘤（OR，1.78; 95%CI，1.01-3.15）和增加体重指数往往会增加风险，特别是粘液性和类胶质瘤tumors.Conclusions：我们证实了已知的风险因素卵巢癌，我们观察到显着差异，粘液性和非粘液性肿瘤之间的风险特征，表明不同的病因。
Objectives: The aim of the study was to examine the overall risk factors for epithelial ovarian cancer and according to histologic subtypes.Materials and Methods: Ovarian cancer cases and controls were recruited from 1995 to 1999, and personal interviews were conducted. A total of 554 cases and 1,564 randomly selected controls were included. The analyses were done using multiple logistic regression models.Results: The overall risk of ovarian cancer decreased with ever being pregnant [odds ratios (OR), 0.40; 95% confidence intervals (0), 0.30-0.55], with increasing pregnancies (OR, 0.63; 95% CI, 0.45-0.87 and OR, 0.51; 95% CI, 0.37-0.69 for two and three pregnancies as compared with one), and with older age at first and last pregnancy, respectively. Increasing years of ovulation was a very strong risk factor with a 7% to 8% increase in risk for each year of ovulation. Use of oral contraceptives (OR, 0.67, 95% CI, 0.53-0.85) and longer duration of use were associated with a decreased risk of ovarian cancer. Ever use of hormone replacement therapy increased the overall risk (OR, 1.30; 95% CI, 1.05-1.61). For all those variables, the effect was present for serous tumors, endometrioid tumors, and tumors of other histologies, but not for mucinous tumors. In contrast, current smoking was a risk factor only for mucinous tumors (OR, 1.78; 95% CI, 1.01-3.15) and increasing body mass index tended to increase the risk especially for mucinous and endometrioid tumors.Conclusions: We confirmed already known risk factors for ovarian cancer, and we observed significant differences in the risk profiles between mucinous and nonmucinous tumors indicating different etiologies.