Anatomical and functional volume concordance between FDG PET, and T2 and diffusion-weighted MRI for cervical cancer: a hybrid PET/MR study
Anatomical and functional volume concordance between FDG PET, and T2 and diffusion-weighted MRI for cervical cancer: a hybrid PET/MR study
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DOI：
10.1007/s00259-013-2668-4
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发表时间：
2014-05-01
影响因子：
9.1
通讯作者：
Wang, Baijun
中科院分区：
文献类型：
--
作者：
Sun, Hongzan;Xin, Jun;Wang, Baijun
为了使用混合全身 PET/MR 评估宫颈癌中 F-18-FDG PET 成像、MR T2 加权 (T2-W) 成像和表观扩散系数 (ADC) 图与扩散加权 (DW) 成像之间的一致性。本研究前瞻性地纳入了 35 名接受治疗前 F-18-FDG PET/MR 成像的宫颈癌患者。使用标准软件融合 F-18-FDG PET 和 MR 图像。最大标准化摄取值 (SUVmax) 的百分比用于在 PET 图像上绘制肿瘤轮廓，并自动计算体积。使用肿瘤面积乘以切片轮廓的标准技术计算在 T2-W 和 DW 图像上测量的肿瘤体积。使用参数统计进行数据分析。使用 SUVmax (14.30 +/- 4.70) 计算的 FDG PET 肿瘤体积和 T2-W 成像体积 (33.81 +/- 27.32 cm(3)) 在 SUVmax 的 35% 和 40% 时相似 (P > 0.05) (32.91 +/- 18.90 cm(3) 和 27.56 +/-分别为 17.19 cm(3)）并且显着相关（P < 0.001；r = 0.735 和 0.766）。平均 DW 体积为 30.48 +/- 22.41 cm(3)。 DW 体积与 35% SUVmax 或 40% SUVmax 时的 FDG PET 体积或 T2-W 成像体积没有显着差异 (P > 0.05)。随着 SUVmax 截止百分比的增加，PET 子体积显示 DW 成像的平均 ADC 值呈反向变化（P < 0.001，方差分析）。混合 PET/MR 显示宫颈癌中 FDG PET、T2-W 和 DW 成像之间的体积一致性很强。对于基于 F-18-FDG PET/MR SUV 的肿瘤体积估计，建议将截止值设为 SUVmax 的 35% 或 40%。 FDG PET 和 DW 成像之间的线性肿瘤亚体积一致性证明了代谢活动和细胞密度的个体区域一致性。
To evaluate the concordance among F-18-FDG PET imaging, MR T2-weighted (T2-W) imaging and apparent diffusion coefficient (ADC) maps with diffusion-weighted (DW) imaging in cervical cancer using hybrid whole-body PET/MR.This study prospectively included 35 patients with cervical cancer who underwent pretreatment F-18-FDG PET/MR imaging. F-18-FDG PET and MR images were fused using standard software. The percent of the maximum standardized uptake values (SUVmax) was used to contour tumours on PET images, and volumes were calculated automatically. Tumour volumes measured on T2-W and DW images were calculated with standard techniques of tumour area multiplied by the slice profile. Parametric statistics were used for data analysis.FDG PET tumour volumes calculated using SUVmax (14.30 +/- 4.70) and T2-W imaging volume (33.81 +/- 27.32 cm(3)) were similar (P > 0.05) at 35 % and 40 % of SUVmax (32.91 +/- 18.90 cm(3) and 27.56 +/- 17.19 cm(3) respectively) and significantly correlated (P < 0.001; r = 0.735 and 0.766). The mean DW volume was 30.48 +/- 22.41 cm(3). DW volumes were not significantly different from FDG PET volumes at either 35 % SUVmax or 40 % SUVmax or from T2-W imaging volumes (P > 0.05). PET subvolumes with increasing SUVmax cut-off percentage showed an inverse change in mean ADC values on DW imaging (P < 0.001, ANOVA).Hybrid PET/MR showed strong volume concordance between FDG PET, and T2-W and DW imaging in cervical cancer. Cut-off at 35 % or 40 % of SUVmax is recommended for F-18-FDG PET/MR SUV-based tumour volume estimation. The linear tumour subvolume concordance between FDG PET and DW imaging demonstrates individual regional concordance of metabolic activity and cell density.