Integrated glycoproteomic characterization of clear cell renal cell carcinoma.
Integrated glycoproteomic characterization of clear cell renal cell carcinoma.
复制标题
透明细胞肾细胞癌的综合糖蛋白组学特征。
DOI：
10.1016/j.celrep.2023.112409
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发表时间：
2023-05-30
期刊：
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
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作者：
Clear cell renal cell carcinoma (ccRCC), a common form of RCC, is responsible for the high mortality rate of kidney cancer. Dysregulations of glycoproteins have been shown to associate with ccRCC. However, the molecular mechanism has not been well characterized. Here, a comprehensive glycoproteomic analysis was conducted using 103 tumors and 80 paired normal adjacent tissues. Altered glycosylation enzymes and corresponding protein glycosylation were observed, while two of the major ccRCC mutations, BAP1 and PBRM1, showed distinct glycosylation profiles. Additionally, inter-tumor heterogeneity and cross-correlation between glycosylation and phosphorylation were observed. The relation of glycoproteomic features to genomic, transcriptomic, proteomic, and phosphoproteomic changes reveals roles of glycosylation in ccRCC development with potential for therapeutic interventions. This study reports a large-scale TMT-based quantitative glycoproteomic analysis of ccRCC which can serve as a valuable resource for the community.
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影响因子：
5.8
作者：
Gu, Zuguang;Eils, Roland;Schlesner, Matthias
通讯作者：
Schlesner, Matthias
影响因子：
7.4
作者：
Toghi Eshghi S;Shah P;Yang W;Li X;Zhang H
通讯作者：
Zhang H
影响因子：
4.1
作者：
Fullam, Anthony;Gu, Lili;Schroeder, Martina
通讯作者：
Schroeder, Martina
影响因子：
8
作者：
Botlagunta, M.;Vesuna, F.;Raman, V.
通讯作者：
Raman, V.
影响因子：
--
作者：
Grauers Wiktorin H;Aydin E;Hellstrand K;Martner A
通讯作者：
Martner A